Accordingly, researchers in both the pharmaceutical industry and academia have been actively seeking MCL-1 inhibitors in the quest for new anti-cancer drugs. Areas covered: This review covers the patent literature on the discovery and development of small-molecule inhibitors of MCL-1 since 2017. ...
近日,药物化学学科权威期刊Journal of Medicinal Chemistry(IF = 6.8)在线发表了沈阳药科大学制药工程学院赵临襄教授课题组在靶向抗凋亡蛋白Mcl-1小分子抑制剂研究领域的最新研究成果,论文题目为“Discovery of Novel Mcl‑1 Inhibitors with ...
5.Li Y, Fan W, Gong Q, et al. Structure-Based Optimization of 3-Phenyl-N-(2-(3-phenylureido) ethyl) thiophene-2-sulfonamide Derivatives as Selective Mcl-1 Inhibitors[J]. Journal of Medicinal Chemistry, 2021. 6.htt...
Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEMcl-1inhibitor19Cat.No.:HY-162780分⼦式:C₄₇H₅₁Cl₂N₅O₇分⼦量:868.84作⽤靶点:Bcl-2Family作⽤通路:Apoptosis储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICAL...
also mutations of MCL-1 are very infrequent (detected in approximately 1% of all cancers) [27] although they were shown to prolong MCL-1 stability and affect the activity of MCL-1 inhibitors [28]. However, MCL-1 stands out as it is one of the most frequently and highly amplified genes...
1. Link between apoptosis and cancer 2. Role of the Bcl-2 family proteins in apoptosis 3. Mcl-1 as a cancer target 4. Structure of Mcl-1 and degradation in cells 5. Various classes of Mcl-1 inhibitors 6. Conclusion Declaration of competing interest Acknowledgement Appendix A. Supplementary...
一种通过破坏 MCL-1 与 BAK 的相互作用来特异性抑制 MCL-1,从而导致癌细胞线粒体凋亡的化合物。 S-55746 1448584-12-0sc-507289 10 mg $750.00 (0) 一种小分子 MCL-1 抑制剂,能有效地将促凋亡蛋白从 MCL-1 中置换出来,导致细胞程序性死亡。
参考文献: [1]. Hekking KFW, et al. Development of Potent Mcl-1 Inhibitors: Structural Investigations on Macrocycles Originating from a DNA-Encoded Chemical Library Screen. J Med Chem. 2024 Feb 22;67 (4):3039-3065.
7-substituted indole mcl-1 inhibitorsCompounds of formula (I) which inhibit the activity of anti-apoptotic McI-I protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated McI-I protein are disclosed.A·J·索尔斯...
In contrast to other Bcl-2 family members, MCL-1 is usually not involved in translocations; also mutations of MCL-1 are very infrequent (detected in approximately 1% of all cancers) [27] although they were shown to pro- long MCL-1 stability and affect the activity of MCL-1 inhibitors [...