HER2positive cases account for 1525% of breast cancer cases, and one of the first events in breast carcinogenesis is HER2 upregulation. Furthermore, HER2 expression increases the detection rate of metastatic or recurrent breast cancers by 5080%. The epidermal growth factor recepto...
MCF-7 cells are useful for in vitro breast cancer studies as a result of the cell line retaining several ideal characteristics particular to the mammary epithelium. These include the ability for MCF-7 cells to process estrogen in the form of estradiol via estrogen receptors in the cell cytoplasm...
A: MCF_7 cells negative for the expression; B: MCF_7 cells transfected with pcDNA 3.1_HER2 positive for HER2 expression, with the membrane stained brown 图4 HER2 在细胞膜上表达的流式细 胞仪检测 i .4 low ytom tri analysis or sur a xpr ssion o $%&2 ...
Interestingly, separate clusters of BC samples were identified to be varying in CRYAB expression, where CRYAB tended to be less expressed in ER-positive BC but more expressed in ER-negative BC111, suggesting a subtype-specific gene expression pattern in CRYAB. While the tumour-suppressive roles ...
HER2+, and triple negative breast cancer (TNBC) categories was not available, IHC data describing ERα, HER2, and PRβ status were downloaded. The tumor samples were separated into the correct intrinsic subtype category based on their positive or negative status of ERα, PRβ, and HER2 as ...
MCF7 is estrogen-receptor-positive and belongs to the luminal A breast cancer subtype [18]. Interestingly, we found higher expression of ATP13A4 in the MCF7 cells as compared to the MCF10A cells, which contributed to increased polyamine uptake and cytotoxicity, as well as the activation of ...
(ER/PR/HER2 positive vs. negative) were reported [76], presented inTable 2. Although there is no significant difference in the survival time relative to the studied miRNAs’ expression, some apparent trends can be recognized, but it may require larger group studies and evaluation of other ...
Similarly, it was discovered that well-differentiated breast carcinomas have higher levels of ER expression than poorly differentiated breast carcinomas [115]. Conversely, ER-low breast tumours were linked to increased Ki-67 expression, negative PR expression, positive HER2 expression, larger size, an...
Pertuzumab, trastuzumab, and docetaxel for HER2-positive metastatic breast cancer (CLEOPATRA) end-of-study results from a double-blind, randomised, placebo-controlled, phase 3 study up-regulation of cdk16 by multiple mechanisms in hepatocellular carcinoma promotes tumor progression.[2017][j exp clin ...
In T47D ER-positive breast cancer cells with mutant p53, we observed minor changes in expression of a small number of genes following PCI-34051 treatment that reflected RAD21 or SMC3 knockdown. However, T47D cells also exhibited severe cell cycle delay following PCI-34051 treatment such that...