病情分析:病情诊断:您所提及的MCF7细胞是乳腺癌研究中常用的一种细胞系,但它本身并不直接代表患者的乳腺癌类型,尤其是三阴性乳腺癌。三阴性乳腺癌是指雌激素受体(ER)、孕激素受体(PR)和人表皮生长因子受体2(HER2)均为阴性的乳腺癌。 病因分析:乳腺癌的具体病因复杂,涉及遗传、激素、生活方式等多种因素。而MCF7...
MCF7是一种乳腺癌细胞系,属于ER阳性乳腺癌。MCF7细胞系是乳腺癌细胞系中较为常见的一个,它是雌激素受体阳性(ER+)的细胞系,这意味着它对雌激素具有较高的亲和力和依赖性。 MCF7细胞系的分子分型有多种,常见的包括: 1. Luminal A型:这种类型的乳腺癌细胞通常表达高水平的ER和PR(孕激素受体),但HER2基因扩增...
人乳腺癌细胞MCF7是早建立的人乳腺癌细胞系之一,激素受体阳性,ER阳性,PR阳性,HER2阴性,常用于雌激素受体信号通路和肿瘤细胞增殖方面的研究。T47D细胞系也是激素受体阳性细胞系,ER和PR均为阳性,HER2阴性,常用于雌激素受体信号通路和肿瘤细胞迁移方面的研究。MDA-MB-231细胞系是HER2阴性、ER阴性、PR阴性的细胞系,具有...
Unlike P53 positive tumors, Miat expression was upregulated in ER, PR, Her2 positive tumor tissues. Knockdown Miat suppressed breast cancer cell proliferation and caused G1 arrest in cell cycle. Furthermore, downregulation of Miat promoted apoptosis and significantly decreased migration of breast ...
临 床数据表明大部分乳腺癌患者的ER a/ER p阳性率显著增加。近10余年来,乳腺癌的研究发展己深入到分子水平的研究,许多癌基因、 抑癌基因、雌激素孕激素受体基因、生长因子受体基因等都发生改变,如HER.2、 ER、PR、C.Myc、Ras、BRCAlt20】等,BRCAl在乳腺癌中的突变不断被发现, HER2是人类表皮生长因子家族的...
epithelium. These include the ability for MCF-7 cells to process estrogen in the form of estradiol via estrogen receptors in the cell cytoplasm. This results in the MCF-7 cell line being an estrogen receptor (ER) positive cell line. MCF-7 is also progesterone receptor positive and HER2 ...
而MDA-B231则是一种从人乳腺腺癌活检中获得的、具有侵袭性的非转移性肿瘤细胞(ER-, PR-),它们表达Herceptin的高水平曲妥珠单抗抗原。这些细胞适合研究针对HER2突变的癌症的治疗方法。MDA-B231不表达雌激素或孕激素受体,可能是复发转移的主要原因之一。总的来说,这两种类型的乳腺癌都有其独特的特征和治疗敏感性特性...
The tumor samples were separated into the correct intrinsic subtype category based on their positive or negative sta- tus of ERα, PRβ, and HER2 as determined by IHC. The scatter plot of NR3C1 mRNA vs intrinsic subtype was created using Microsoft Excel software. The graphs and table ...
Secondly, FOXP3 represses several key target genes in cancer development, such as BRCA1 [12], CD44 [13], HER2/ERBB2 [11], and SKP2 [14], providing a strong link between FOXP3 and DNA repair system, as well as FOXP3 and cell cycle regulation. Thirdly, the FOXP3-miR-146-NF-κB ...