The growth of breast cancer cells is controlled by PR & ER as well as plasma membrane-associated growth factor receptors. Two particularly important members of this large family are EGFR activated by EGF, and the epidermal growth factor receptor 2 (HER-2). Links MCF-7 Xenograft CRO Services ...
HCC827细胞系;细胞传代方法:消化5分钟。1:2。4-5天长满;细胞形态特性:上皮细胞样;细胞生长特性:贴壁生长;细胞背景资料:这株细胞建于1994年三月。这株肺腺癌在EGFR酪酸激酶区域有一个获得性突变(E746-A750缺失)。患者在25岁到26岁时每个月抽1包烟。在诊断前12年不再抽烟。
Inhibition of EGF induced EGFR activation, cell viability and colony formation of MCF7 cells by DPDIM.Arijit, Bhowmik
Anti-Phospho-EGFR(Tyr1086) /FITC 荧光素标记兔抗人、大、小鼠磷酸化表皮生长因子受体抗体IgGMulti-class antibodies规格: 0.2ml表皮葡萄球菌 anti-CXCL10/IP-10 /FITC 荧光素标记CXCL10趋化因子10/干扰素诱导蛋白10抗体IgGMulti-class antibodies规格: 0.2ml表皮葡萄球菌冻干粉 ...
本实验通过使用针对表皮生长因子受体(EGFR)的单克隆抗体西妥昔单抗作用于体外生长的MCF-7乳腺癌细胞系他莫昔芬(TAM)耐药株(MCF-7/TAMR),观察药物对细胞增殖的影响,通过对比检测用药前后细胞FUT4和LeY表达水平的变化,初步探讨西妥昔单抗抑制MCF-7/TAMR细胞增殖的分子机制。 方法:实验选用上皮来源的乳腺癌细胞系MCF...
氟西汀调节星形胶质细胞erk磷酸化的机制——5-ht_,2b_受体介导的egfr间接激活 热度: 磷酸化-去磷酸化与细胞分化进程 热度: 磷酸化调控的细胞命运 热度: 隶南『大・坚硕士学位论文MCF-7细胞MLC2磷酸化的不同途径差异性调节TREl7诱导Arf6和NF-KB激活的初步研究 ...
发挥关键作用,它与其他 EGFR 一起,通过复杂的信 号网络调节细胞生长、分化 [6] 。 HER 在胎盘、胚胎上 皮组织及很多肿瘤细胞中呈高表达,而在正常组织中 为阴性或微量表达 [7] 。 临床研究发现,乳腺癌细胞中 ER表达阳性时 HER 表达常为阴性, 而 HER 高表 ...
Results The results showed that FFJ-5 inhibited the growth of MCF7,inhibited the expression and activity of EGFR and Akt,and consequently reduced the expression of PKM2 in MCF7 cells; FFJ-5 activated caspase-3 and induced genomic DNA fragmentation; FFJ-5 also inhibited the growth of MCF7 /...
In this review, single-chain fragment variable construction using phage-display technology as a promising anticancer immunotherapy technology is described. Cloning and the specific bio-panning selection with phage display technology, as well as the use of the epidermal growth factor receptor (EGFR) at...
The HOXB7 protein renders breast cancer cells resistant to tamoxifen through activation of the EGFR pathway Proc. Natl. Acad. Sci. U.S.A., 109 (8) (2012), pp. 2736-2741 CrossrefView in ScopusGoogle Scholar [7] S. Liu HOXB7 promotes malignant progression by activating the TGF beta sign...