姜黄素干预MCD饮食诱导的小鼠NASH的作用机制 TheinterventionmechanismofcurcuminonMCDdiet-inducedNASHinmice 诸葛丽 北京中医药大学东方医院消化内科 摘要:目的研究姜黄素干预非酒精性脂肪性肝炎(non-alcoholicsteatohepatitis,NASH) 的作用机制。方法采用胆碱蛋氨酸缺乏(Methionine-Choline-Deficient,MCD)饮食诱 导的小鼠NASH模型...
Male mice were fed a NASH‐inducing (methionine‐choline‐deficient) MCD diet with or without naringenin supplementation for 6 weeks. Naringenin prevented NASH‐induced histopathological liver damage and reversed the abnormal levels of hepatic triglyceride (TG)/total cholesterol (TC), serum...
Blood, adipose tissues and gut parameters of ATH- and MCD-induced NASH models We challenged C57BL/6J male mice with two different diets: a diet deficient in methionine and choline (MCD) for 7 weeks or an atherogenic (ATH) diet rich in lipids, cholesterol and cholate for 12 weeks. From ...
This study delves into the therapeutic implications of exosomes derived from SCAPs in the methionine-choline-deficient (MCD) diet-induced mice non-alcoholic steatohepatitis (NASH) model. We extracted exosomes from SCAPs. During the last two weeks of the MCD diet, mice were intravenously administered...
MCDNASH脂肪肝 戴茨生物科技(无锡)有限公司 地址:无锡市惠山区惠山大道1719-5号4层 电话:***-***811 info@dyets-cn .dyets-cnVersion20200305 蛋氨酸及胆碱缺乏饲料 (MethionineandCholineDeficientL-AminoAcidDiet) 货号:MCD(美国货号519580) 储存条件:-20度,保持干燥 Ingredient,成分单位热量值(kcal/g)重量(gra...
Methods:Male C57BL/6 mice were fed a methionine-choline-deficient (MCD) diet or a standard diet for 17 days, following which they were injected with lipopolysaccharide (LPS) intraperitoneally and sacrificed after 6h. In an in vitro ... Min Kyung Chae,Hyun Chul Lee,Byungwan Lee 被引量: 0...
NAFLD/NASH发病特征 食源性肥胖和胰岛素抵抗是最常见的人类代谢疾病的诱因,各类特制饲料常用在NAFLD/NASH造模中。 MCD(Methionine- and choline-deficient diet)造模:MCD饮食中缺乏蛋氨酸和胆碱,蛋氨酸是合成半胱氨酸的关键化合物,胆碱是乙酰胆碱的前体,它们是肝脏和成磷脂酰胆碱的必要原料,缺乏磷脂酰胆碱会导致极低密度脂...
In the present study, we combine histological, transcriptional and lipidomic approaches to dissociate common and specific alterations induced by two classical dietary NASH models (atherogenic (ATH) and methionine/choline deficient (MCD) diet) in C57BL/6J male mice. Despite a similar degree of ...
As mouse feeding with methionine- and choline-deficient (MCD) diet is a model of lean NASH, we tested whether iPla2 beta-null mice could still be protected since PL syntheses are disturbed. MCD-diet feeding of female wild-type for 5 weeks induced hepatic steatosis with a severe reduction ...
In the current study, we analyzed Tim-3 expression on different subpopulations of liver macrophages and further investigated the potential roles of Tim-3 on hepatic macrophages in methionine and choline-deficient diet (MCD)-induced NASH mice. The results of flow cytometry demonstrated the ...