showed that by simply changing the Western diet in a mouse model to a normal chow diet, where calories are derived from proteins and carbohydrates rather than fats, with no cholesterol, NASH and liver fibrosis were improved; and cancer progression and mortality prevented...
NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat ...
The aim of the present study was to determine if FATZO mice fed a high fat and fructose diet would exacerbate the progression of NAFLD/NASH. 展开 关键词: Metabolic disease, Liver disease, NAFLD, NASH, FATZO mouse DOI: 10.1186/s12876-019-0958-4 年份: 2019 ...
a type of white blood cell, in the liver. Using amouse model, the study details the cascade of events in theimmune systemthat eventually leads to the type of liver inflammation and scarring that is commonly seen in patients with NASH. ...
Augmented liver inflammation in a microsomal prostaglandin E synthase 1 (mPGES-1)-deficient diet-induced mouse NASH modelIn a subset of patients, non-alcoholic fatty liver disease (NAFLD) is complicated by cell death and inflammation resulting in non-alcoholic steatohepatitis (NASH), which may ...
A mouse model of diet-induced obesity and insulin resistance. Methods Mol. Biol. 821, 421–433 (2012). Article CAS Google Scholar Malaguarnera, M. et al. L-carnitine supplementation to diet: a new tool in treatment of nonalcoholic steatohepatitis-a randomized and controlled clinical trial. ...
Cenicriviroc (CVC), a dual chemokine receptor 2 and 5 antagonist, prevents macrophage trafficking and is under clinical investigation for the treatment of human NASH fibrosis. We assessed the efficacy and durability of short and prolonged CVC therapy in a diet‐induced mouse model of NASH, the ...
(with well-controlledserum cholesterollevels); used mathematical modeling to demonstrate how this stem cell proliferation accelerates development of CHIP clones; and finally confirmed more rapid clonal expansion in an atherogenic mouse model withTet2-deficient bone marrow in mice fed an atherogenic vs ...
(Lactobacillus, Clostridium IV,ButyricicoccusandPseudoflavonifractor). Further, altered abundances ofCandida, Alternaria,Wallemia, andLactobacilluswere reported in the gut of the dextran sulfate sodium-induced colitis mouse model64. Additionally, dysbiosis characterized by underrepresentation of the butyrate-...
inefficient extraction of specific protein classes and difficulties with identifying small proteins. The present study demonstrate that transcriptomics analysis provides the most comprehensive dissection of the molecular signature of the DIO-NASH mouse model. However, as changes in mRNA level was not consis...