In the present study, we combine histological, transcriptional and lipidomic approaches to dissociate common and specific alterations induced by two classical NASH-inducing models, namely the atherogenic diet and methionine and choline deficient diet. We showed that both ATH and MCD diets increased live...
非酒精性脂肪肝(Non-alcoholic fatty liver disease,NAFLD)是由于多种原因导致肝脏脂肪积累而引起的一组疾病,其中包括简单脂肪肝(simple fatty liver)、非酒精性脂肪性肝炎(non-alcoholic steatohepatitis,NASH)和肝纤维化(liver fibrosis)等。 MCD脂肪肝模型(methionine and choline deficient diet-induced fatty liver ...
在NAFLD/NASH的研究中,动物模型的构建至关重要。MCD饲料(Methionine and Choline Deficient Diet,蛋氨酸和胆碱缺乏饲料)是一种经典的用于诱导实验动物非酒精性脂肪肝的饲料,其中A02082002BR是一种常用的MCD饲料。本文将详细介绍A02082002BR的成分、特点及其在科研中的应用。 1. A02082002BR的基本信息 A02082002BR是一...
As mouse feeding with methionine- and choline-deficient (MCD) diet is a model of lean NASH, we tested whether iPla2 beta-null mice could still be protected since PL syntheses are disturbed. MCD-diet feeding of female wild-type for 5 weeks induced hepatic steatosis with a severe reduction ...
This study delves into the therapeutic implications of exosomes derived from SCAPs in the methionine-choline-deficient (MCD) diet-induced mice non-alcoholic steatohepatitis (NASH) model. We extracted exosomes from SCAPs. During the last two weeks of the MCD diet, mice were intravenously administered...
Lipopolysaccharide triggered TNF-a-induced hepatocyte apoptosis in a murine non-alcoholic steatohepatitis model Methods:Male C57BL/6 mice were fed a methionine-choline-deficient (MCD) diet or a standard diet for 17 days, following which they were injected with lipopolysaccharide (LPS) intraperitoneally...
NAFLD/NASH发病特征 食源性肥胖和胰岛素抵抗是最常见的人类代谢疾病的诱因,各类特制饲料常用在NAFLD/NASH造模中。 MCD(Methionine- and choline-deficient diet)造模:MCD饮食中缺乏蛋氨酸和胆碱,蛋氨酸是合成半胱氨酸的关键化合物,胆碱是乙酰胆碱的前体,它们是肝脏和成磷脂酰胆碱的必要原料,缺乏磷脂酰胆碱会导致极低密度脂...
Metabolic impact of partial hepatectomy in the non-alcoholic steatohepatitis animal model of methionine-choline deficient diet In this scenario, partial hepatectomy (PH) is an alternative to promote liver regeneration. However, as liver regeneration is impaired in NASH patients, ... EC A,MPVB C,BL...
The biological activity and treatment efficacy of C-192 were confirmed both in vitro and in vivo using a methionine-choline-deficient (MCD) diet-induced mouse model. C-192 exhibited profound therapeutic efficacies compared to conventional drugs, including liraglutide and dulaglutide. C-192 ...
Hence, it has been shown that microbiota depletion can ameliorate high-fat diet or western-diet induced experimental Non-alcoholic steatohepatitis (NASH). However, its functional implications in the methionine-choline dietary model, remain incompletely understood. Here, we investigated the physiological ...