Genetic deletion of maternal TDP-43 results in mouse early embryos arrested at the two-cell stage. TDP-43 co-occupies with RNA Pol II as large foci in the nucleus and also at the promoters of ZGA genes at the late two-cell stage. Biochemical evidence indicates that TDP-43 binds Polr2a ...
Multivalent GU-rich oligonucleotides sequester TDP-43 in the nucleus by inducing high molecular weight RNP complexes iScience, Volume 27, Issue 6, 2024, Article 110109 Xi Zhang,…, Lindsey R. Hayes View PDF Community metabolic modeling of host-microbiota interactions through multi-objective optimizatio...
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