Mass spectrometry imaging (MSI) is an emerging technology that holds potential for improving, biomarker discovery, metabolomics research, pharmaceutical applications and clinical diagnosis. Despite many solutions being developed, the large data size and high dimensional nature of MSI, especially 3D datasets...
质谱成像(Mass Spectrometry Imaging，简称MSI)是一种用于研究生物分子分布和空间分布的分析技术。它结合了质谱分析和成像技术，可以在细胞、组织和生物样品中实现高分辨率的空间分布分析。质谱成像的应用领域包括生物医学研究、药物开发、环境科学等。质谱成像的基本原理是利用质谱仪进行分子的离子化和检测。首先，样品表面上...
However, if the datasets were reduced to the mass spectral features detected in each experiment the reduced data load would allow molecular histology of small tissue arrays (Table 1). Table 1. Typical dataloads for clinical tissue analyses using MALDI imaging mass spectrometry prior to feature ...
Spatial proteomics has the potential to significantly advance our understanding of biology, physiology and medicine. Matrix-assisted laser desorption/ionisation mass spectrometry imaging (MALDI-MSI) is a powerful tool in the spatial proteomics field, ena
Mass spectrometry imaging (MSI) has become a powerful tool to probe molecule events in biological tissue. However, it is a widely held viewpoint that one of the biggest challenges is an easy-to-use data processing software for discovering the underlying biological information from complicated and ...
Mass Spectrometry Imaging (MSI) holds significant promise in augmenting digital histopathologic analysis by generating highly robust big data about the metabolic, lipidomic and proteomic molecular content of the samples. In the process, a vast quantity o
Achieving and maintaining high mass measurement accuracy (MMA) throughout a mass spectrometry imaging (MSI) experiment is vital to the identification of the observed ions. However, when using FTMS instruments, fluctuations in the total ion abundance at each pixel due to inherent biological variation ...
质谱成像(Mass Spectrometry Imaging,简称MSI)是一种用于研究生物分子分布和空间分布的分析技术。它结合了质谱分析和成像技术,可以在细胞、组织和生物样品中实现高分辨率的空间分布分析。质谱成像的应用领域包括生物医学研究、药物开发、环境科学等。 质谱成像的基本原理是利用质谱仪进行分子的离子化和检测。首先,样品表面上...
Mass Recalibration of FT-ICR Mass Spectrometry Imaging Data Using the Average Frequency Shift of Ambient Ions. J. Am. Soc. Mass Spectrom. 24, 1137–1145 (2013). https://doi.org/10.1007/s13361-013-0659-0 Download citation Received28 March 2013 Revised29 April 2013 Accepted29 April 2013 ...
Data processing for three dimensional mass spectrometry (3D-MS) imaging was investigated, starting with a consideration of the challenges in its practical implementation using a series of sections of a tissue volume. The technical issues related to data reduction, 2D imaging data alignment, 3D visual...