imaging mass spectrometryMALDImass spectrometry imagingSIMSThe use of mass spectrometry (MS) to acquire molecular images of biological tissues and other substrates has developed into an indispensable analytical tool over the past 25 years. Imaging mass spectrometry technologies are widely used today to ...
Direct profiling of proteins in biological tissue sections by MALDI mass spectrometry. Anal. Chem. 71, 5263–5270 (1999). Article CAS Google Scholar Stoeckli, M., Farmer, T.B. & Caprioli, R.M. Automated mass spectrometry imaging with a matrix-assisted laser desorption ionization time-of-fl...
质谱成像(Mass Spectrometry Imaging，简称MSI)是一种用于研究生物分子分布和空间分布的分析技术。它结合了质谱分析和成像技术，可以在细胞、组织和生物样品中实现高分辨率的空间分布分析。质谱成像的应用领域包括生物医学研究、药物开发、环境科学等。质谱成像的基本原理是利用质谱仪进行分子的离子化和检测。首先，样品表面上...
Imaging mass spectrometry combines the chemical specificity and parallel detection of mass spectrometry with microscopic imaging capabilities. The ability to simultaneously obtain images from all analytes detected, from atomic to macromolecular ions, allows the analyst to probe the chemical organization of a...
Imaging Mass Spectrometry is a highly sensitive molecular imaging technique that combines molecular information with spatial resolution, allowing for the identification and localization of elements and molecules directly from tissue sections and single cells. ...
Imaging mass spectrometry combines the chemical specificity and parallel detection of mass spectrometry with microscopic imaging capabilities. The ability to simultaneously obtain images from all analytes detected, from atomic to macromolecular ions, allows the analyst to probe the chemical organization of a...
In this context, liquid-chromatography coupled to high resolution mass spectrometry (LC-HRMS) is increasingly used an... PM Allard,T Péresse,J Bisson,... - 《Analytical Chemistry》 被引量: 41发表: 2016年 Imaging Mass Spectrometry of a Coral Microbe Interaction with Fungi Fungal infections ...
To further understand these glycan epitopes, an imaging mass spectrometry (IMS) approach was used to assess the N-glycome of the human pancreas and pancreatic cancer in a cohort of patients with PDAC represented by tissue microarrays and whole-tissue sections. Orthogonally, these same tissues were...
Mass spectrometry imaging (MSI) and mass spectrometry (MS) profiling are two especially suitable methods for recording and visualizing microscopic molecular details. Mass spectrometry imaging of larger molecules, such as proteins and intact peptides, was demonstrated using a gentler imaging technique, ...
Hand-cut sections of stems of two Eucalyptus species were covered with silica and directly analyzed by matrix-assisted laser sesorption ionization (MALDI)-imaging mass spectrometry (MS). Information available in the literature about soluble lignin subunits and structures were used to trace their ...