Chace, Donald HChace DH. Method for interpreting tandem mass spectrometry data for clinical diagnosis. US Patent No. 6,455,321 B1, September 24, 2002.
Developments in mass spectrometry (MS) instrumentation have supported the advance of a variety of proteomic technologies that have enabled scientists to assess differences between healthy and diseased states. In particular, the ability to identify altere
Determination of the empirical formula of peptides by fast atom bombardment mass spectrometry A method for calculating the empirical formulae of peptides from mass spectrometric data is described. Exact mass measurement data and isotopic peak ratios are used to generate a list of potential empirical ...
In this final session of this 3 part seris we will review hot to process and interpret resulting data. We will review how best to collect targeted and non-targeted MS data as well as the basic considerations for qualitative and quantitative as...
RATIONALE Soft ionization, high-resolution mass spectrometry is widely used to characterize large biological molecules, such as proteins. Deconvolution ('deisotoping') of isotopic envelopes (iEs) in biological mass spectra into monoisotopic or average masses is challenging due to low signals and heavil...
Interpreting electron transmission spectroscopy and negative ion mass spectrometry data using a spherical potential well modelInterpreting electron transmission spectroscopy and negative ion mass spectrometry data using a spherical potential well modelTheoretical or Mathematical/ electron attachmentelectron...
Buprenorphine urine testing can be performed using immunoassay (IA), gas chromatography-mass spectrometry (GC–MS), and liquid chromatography-tandem mass spectrometry (LC–MS/MS) assays. GC–MS and LC–MS/MS can quantify the concentration of buprenorphine and its metabolites in the urine and gener...
Once these problems are solved, the use of artificial intelligence in data driven systems biology through the integration of multi-omics will be a key next step in solving the genotype-phenotype problem. Conclusions The remarkable advances in imaging, sequencing, and mass spectrometry technologies ...
We introduce PHOXTRACK (PHOsphosite-X-TRacing Analysis of Causal Kinases), a user-friendly freely available software tool for analyzing large datasets of post-translational modifications of proteins, such as phosphorylation, which are commonly gained by mass spectrometry detection. In contrast to other...
13.7 Spin-Spin Splitting in 1H NMR Spectroscopy Not all peaks are singlets. Signals can be split by coupling of nuclear spins. 12 Figure 13.13 Cl2CHCH3 4 lines; quartet 2 lines; doublet CH3 CH 1.0 2.0 3.0 4.0 5.0 6.0 7.0 8.0 9.0 10.0 Chemical shift (, ppm) 1 ...