The spatial immune landscape of MBM with and without LD remains poorly understood.Methods:To spatially characterize the tumor microenvironment (TME) of MBM, we performed CyTOF Imaging Mass Cytometry (CyTOF-IMC) on a highly multiplexed panel of 35 antibodies for 21 MBMs (13 with LD, 8 without ...
Inter-cellular crosstalk between MDMs and microglia orchestrated anti-inflammatory and repair-promoting microglia phenotypes and promoted post-stroke neurogenesis, with SOX2 and related Akt/CREB signaling as the underlying mechanisms. This description of the brain’s immune landscape and its relationship ...
for stress-induced, tRNA-driven, codon-biased translation. AQRNA-seq thus provides a versatile means to quantitatively map the small RNA landscape in cells. Access options Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription...
Genome-scale flux balance models of metabolism provide testable predictions of all metabolic rates in an organism, by assuming that the cell is optimizing a metabolic goal known as the objective function. We introduce an efficient inverse flux balance an
Genome-scale flux balance models of metabolism provide testable predictions of all metabolic rates in an organism, by assuming that the cell is optimizing a metabolic goal known as the objective function. We introduce an efficient inverse flux balance an
Supervised deep learning approaches have proven powerful, but are inherently limited by the cost and quality of annotations used for training. Therefore, we present Histomorphological Phenotype Learning, a self-supervised methodology requiring no labels and operating via the automatic discovery of ...
many restricted to distinct progenitor cell types and/or brain regions are identified. This dataset defines a “ground truth” epigenomic landscape and reveals a diverse chromatin landscape. The data can be used to explore...
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Recent advances have led to increasing interest in mapping the brain connectomic landscape underlying 1) traits relevant for brain and mental health and 2) their genetic underpinnings. To this end, we conducted a large-scale integration of advanced measures of fMRI-based brain FC in a population ...
the international immuno-oncology biomarkers working group: Part 2: Tils in melanoma, gastrointestinal tract carcinomas, non-small cell lung carcinoma and mesothelioma, endometrial and ovarian carcinomas, squamous cell carcinoma of the head and neck, genitourinary carcinomas, and primary brain tumors. ...