Spatial transcriptomic technologies promise to resolve cellular wiring diagrams of tissues in health and disease, but comprehensive mapping of cell types in situ remains a challenge. Here we present сell2location, a Bayesian model that can resolve fine-
With these prerequisites in mind, we designed a deep neural network for directed single-cell expression reconstruction (DISCERN) (Additional file1: Fig. S1B) that is based on a modified Wasserstein Autoencoder [25]. A unique feature of DISCERN is that it transfers the “style” of hq onto ...
Typical methods to investigate CWI maintenance mechanisms involve the use of chemical agents or active enzymes to cause CWD (Engelsdorf et al.2018). Cellulose is the main load-bearing component of cell walls and has been targeted by cellulose biosynthesis inhibitors (CBIs), like isoxaben (Desprez ...
Remarkably, Tangram not only predicted expression for genes that were not measured by STARmap, but effectively corrected the spatial expression of low-quality genes (Fig.3c–e), as compared with the performance of Allen Brain Atlas (http://atlas.brain-map.org/atlas?atlas=1) ISH. First, when...
Compared to the commonly used Si-based solar cells,polymer solar cells(PSCs) have promising advantages, such as light weight, flexibility, and easy integration with other electronic devices. Similar to the structure of flexible DSSCs, plastic substrates have been employed to prepare flexible PSCs,...
HemaBook Chapter 6: Mindray's solution for solving in-vitro PLT aggregation PLT aggregation problem may be solved by blocking the PLT activation process. In order to discover the mechanism of PLT activation, we carried out a further exploration into the subcellular structure and cellular signaling...
It is important to keep this in mind when developing Erk-inhibiting pharmaceuticals to avoid the waning of effects over time. To explain the increase in MAPK3/1 (ERK1/2) target expression, it has been suggested that the nuclear lamina acts as a scaffold for MAPK3/1 (ERK1/2). It ...
1) the inference of the global lineage structure and 2) the inference of pseudotime variables for cells along each lineage (Fig.1). Like other methods [7,10], Slingshot’s first stage uses a cluster-based MST to stably identify the key elements of the global lineage structure, i.e., th...
Despite the emergence of experimental methods for simultaneous measurement of multiple omics modalities in single cells, most single-cell datasets include only one modality. A major obstacle in integrating omics data from multiple modalities is that diff
Chromosome structure is a crucial regulatory factor for a wide range of nuclear processes. Chromosome conformation capture (3C)-based experiments combined with computational modelling are pivotal for unveiling 3D chromosome structure. Here, we introduce TADdyn, a tool that integrates time-course 3C data...