Studying the variation of gene expression is essential for understanding cellular and molecular biology. Gene expression can vary significantly across different cell types, and that the composition of cell types can vary across tissue samples1. As a result, variation in gene expression observed in bul...
European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany Artem Lomakin, Moritz Gerstung & Oliver Stegle Center for Computational Biology, University of California, Berkeley, Berkeley CA, USA Adam Gayoso Theory of Condensed Matter, Department of Physics, Cavendish Laboratory, Universi...
With these prerequisites in mind, we designed a deep neural network for directed single-cell expression reconstruction (DISCERN) (Additional file1: Fig. S1B) that is based on a modified Wasserstein Autoencoder [25]. A unique feature of DISCERN is that it transfers the “style” of hq onto ...
Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA Kristy Red-Horse Howard Hughes Medical Institute, Stanford, CA, USA Kristy Red-Horse Contributions J.S., R.H.A. and M.E.P. designed the study. J.S. performed the vast majo...
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Besides providing a broad reference map for developmental biology and regenerative medicine, we directly demonstrate the applications of this roadmap to produce engraftable human tissue progenitors and provide insight into developmental signaling dynamics, chromatin remodeling, and congenital disease. ...
biology, and physical education. Known as a great thinker, Plato was also an athlete and competitive wrestler. Besides using science to break things down to their component parts, he also was a great believer in balance especially between the body and mind. He told his students to balance int...
November 22, 2024 Maps can tell you where to go and what landmarks you’ll find along the way. In the same way, a new multiomic map describes how DNA methylation and 3D chromatin conformation changes in the prefrontal cortex and hippocampus as the human brain develops. The map could help...
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One can imagine that a model able to capture the features of single cells with much finer resolution will surely be powerful in mapping the cellular structure and facilitating new discoveries in cell biology through modeling the multi-scale proteome architecture. It is expected that the learned ...