We computed CellRank’s directed transition matrix, and then coarse-grained it into 12 macrostates (Fig.2b) based on eigenvalue gap analysis (Supplementary Fig.1a,b), revealing a block-like structure in the transition matrix (Fig.2cand Extended Data Fig.4a–c). Macrostates, annotated accordi...
E. Three-dimensional structure of a human connexin26 gap junction channel reveals a plug in the vestibule. Proc. Natl Acad. Sci. USA 104, 10034–10039 (2007). Article ADS PubMed PubMed Central CAS Google Scholar Garrod, D. & Chidgey, M. Desmosome structure, composition and function. ...
Haematopoietic stem cells niches: Interrelations between structure and function The idea that stem cells are maintained in a specialized microenvironment that is commonly known as the “stem-cell niche” originates from studies on mammalianhaematopoietic stem cells[1].Stem cell nichesare firstly defined...
These modalities can also lead to single-cell imaging capabilities by targeting endogenous cell contrast or by employing exogenous contrast generation techniques, including contrast agents that target specific cell structure or function. In this review, we present key developments, summarize recent ...
Cell-based architecture is different from your everyday structure. It requires a team with specific skills — expertise in distributed systems and cloud technologies and a deep understanding of the business domains they are working with.最后,我们来谈谈技能和专业知识。基于单元的架构与您的日常结构不同...
It remains poorly understood how different cells in a tissue organize and coordinate with each other to support tissue functions. To better understand the structure-function relationship of a tissue, the concept oftissue cellular neighborhoods (TCNs) or spatial domainsas well as their identification to...
The liver sieve: considerations concerning the structure and function of endothelial fenestrae, the sinusoidal wall and the space of Disse. Hepatology. 1985;5:683–92. Article CAS PubMed Google Scholar DeLeve LD. Liver sinusoidal endothelial cells and liver regeneration. J Clin Investig. 2013;...
trades off the attractive and repulsive terms, while parameter β trades off the composite weights of data disparities in high-dimensional space and time intervals on the repulsive term. by fixing λ , a smaller β will have smaller effects by the temporal order/structure of samples, leading to...
The structure and function was annotated on a sequence segment/domain-wise basis. After extensive literature search and curation using the sequence architecture, 345 gene products were mapped onto known pathways, possible cellular roles, and subcellular localizations (Figure 4) using the PathwayExplorer...
. We project the seed cells onto the embedding graph and assign the seed cells to an even probability distribution representing the initial state of the cell-to-cell graph. As the graph is undirected, information propagated from the initial seed cells is based only on the structure and ...