The results suggested that by using the combination of Lopinavir, Ritonavir along with Hydroxychloroquine and Vitamin C may turned out to be the effective line of treatment for SARS–CoV–2 as it shows the involvement of PARP–1, MAPK–8, EGFR, PRKCB, PTGS–2, and BCL–2. Gene ontology ...
Monoclonal antibodies targeting a variety of epitopes have been isolated from individuals previously infected with SARS-CoV-2, but the relative contributions of these different antibody classes to the polyclonal response remains unclear. Here we use a yeast-display system to map all mutations to the ...
Monoclonal antibodies targeting a variety of epitopes have been isolated from individuals previously infected with SARS-CoV-2, but the relative contributions of these different antibody classes to the polyclonal response remains unclear. Here we use a ye
SARS-CoV-2 is a major threat to global health. Here, we investigate the RNA structure and RNA-RNA interactions of wildtype (WT) and a mutant (Δ382) SARS-CoV-2 in cells using Illumina and Nanopore platforms. We identify twelve potentially functional structural elements within the SARS-CoV-...
Severe SARS-CoV-2 infection often leads to development of acute respiratory distress syndrome (ARDS), with profound patho-histological changes in post-mortem ludoi:10.2139/ssrn.3673600Margaroli, CamillaBenson, P.Sharma, NirmalMadison, Matthew
SARS-CoV-2 Variant surveillance Genomic surveillance of SARS-CoV-2 lineages in New Haven, CT Read the latest Connecticut report → Yale SARS-CoV-2 Surveillance Initiatives We're using viral sequencing and phylogenetics to learn more about how SARS-CoV-2
CRISPR arrays contain spacers, some of which are homologous to genome segments of viruses and other parasitic genetic elements and are employed as portion of guide RNAs to recognize and specifically inactivate the target genomes. However, the fraction of the spacers in sequenced CRISPR arrays that...
The receptor-binding domain (RBD) is immunodominant and the target of 90% of the neutralizing activity present in SARS-CoV-2 immune sera. Whereas overall RBD-specific serum IgG titers waned with a half-life of 49 days, nAb titers and avidity increased over time for some individuals, ...
Structural assessment of HLA-A2-restricted SARS-CoV-2 spike epitopes recognized by public and private T-cell receptors Daichao Wu,Alexander Kolesnikov,Rui Yin,... - 《Nature Communications》 - 2022 - 被引量: 0 Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-...
There are comments on PubPeer for publication: Complete mapping of mutations to the SARS-CoV-2 spike receptor-binding domain that escape antibody recognition (2020)