Results We show thatSchizosaccharomyces pombecells lacking Pmk1, the MAP kinase effector of the cell integrity pathway (CIP), are hypersensitive to microtubule damage and defective in maintaining a metaphase arrest. Epistasis analysis suggests that Pmk1 is involved in maintaining spindle assembly checkpoi...
Therefore, using this driver provided the additional advantage of being able to examine the effects of Gem and Brm expression on the EGFR–Ras–MAPK signaling pathway in the wing disc independent of effects on the cell cycle. We have previously shown that C96-GAL4-induced expression of brmDN ...
the mitogen activated protein kinase and the phosphoinositide 3-kinase signaling pathways are commonly altered, and therapeutically inhibiting one of the pathways often upregulates the other, leading to resistance. Thus, combined treatment targeting both pathways is a promising strategy to overcome this....