SCP3 has significant immunomodulatory potential. The underlying molecular mechanism was that SCP3 activates macrophages via TLR4 receptors to promote ROS production, which in turn activates the downstream MAPK/NF-κB signalin...
SCP3 has significant immunomodulatory potential. The underlying molecular mechanism was that SCP3 activates macrophages via TLR4 receptors to promote ROS production, which in turn activates the downstream MAPK/NF-κB signaling pathway and then
氟化钠可通过MAPK/ NF-κB 通路 的激活,提高COX-2 和促炎因子的表达,抑制抗炎因子的表达,诱导肝脏炎症 I 反应的发生。故MAPK/NF-κB 信号通路的激活以及促炎和抗炎细胞因子表达的 改变是氟化钠诱导肝脏炎症反应发生可能的分子基础。 关键词:氟化钠;肝脏;小鼠;炎症反应;NF-κB ;MAPK ...
NF-kappa BSignal TransductionThe induction of interleukin-6 (IL-6) using a proinflammatory cytokine (IL-1beta) was studied in human gingival fibroblasts (HGFs) in relation to p38 MAPK and NF-kappaB transcription factor. When added to HGFs, IL-1beta had a stimulatory effect on the production...
This study was designed to evaluate the antitumor activity of low-molecular-weight β-glucan (LMBG) produced by gamma irradiation (50 kGy), using in vivo and in vitro models.RESULTSThe results indicate that treatment with LMBG increased the proliferation of murine peritoneal macrophages, and their...
The mechanisms underlying such anti-inflammatory actions included the regulation of phosphorylation of related proteins to monitor the expressions of inflammatory mediators and genes in the nuclear factor kappa-B (NF-κB) and ...
kappa-B (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways. Therefore, the phenolic extract fromC. speciosais a desirable anti-inflammatory agent for inflammatory conditions to meet the rising demand for natural and cost-effective therapeutics....
Diallyl disulfide inhibits TNFα induced CCL2 release through MAPK/ERK and NF-Kappa-B signaling. Cytokine 2015; 75: 117-126.Bauer D, Redmon N, Mazzio E, Taka E, Reuben JS, et al. (2015) Diallyl disulfide inhibits TNFalpha induced CCL2 release through MAPK/ERK and NF-Kappa-B signaling...
[13] Qian Y, Zhao Z, Jiang Z, Li X. Role of NF kappa B activator Act1 in CD40-mediated signaling in epithelial cells. Proc. Natl. Acad. Sci. U S A. 2002 Jul 9;99(14):9386-91. PubMed ID: 12089335 [14] Li H, Nord EP. CD40 ligation stimulates MCP-1 and IL-8 production,...
首次探究了丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)、蛋白激酶B(protein kinase B,AKT)和核因子κB(nuclear factor kappa B,NF-κB)信号通路在温和气单胞菌诱导宿主细胞炎性应答中的作用及相关的分子机制,并分别从...