SCP3 has significant immunomodulatory potential. The underlying molecular mechanism was that SCP3 activates macrophages via TLR4 receptors to promote ROS production, which in turn activates the downstream MAPK/NF-κB signalin...
SCP3 has significant immunomodulatory potential. The underlying molecular mechanism was that SCP3 activates macrophages via TLR4 receptors to promote ROS production, which in turn activates the downstream MAPK/NF-κB signaling pathway and then
The mechanisms underlying such anti-inflammatory actions included the regulation of phosphorylation of related proteins to monitor the expressions of inflammatory mediators and genes in the nuclear factor kappa-B (NF-κB) and ...
Modulation of dendritic cell mapk and NF-kappa B expression by Leishmania amazonensis prevents proper dendritic cell maturationGhosh, MBoggiatto, P MJie, FWilson, DJones, DPetersen, C
氟化钠通过激活MAPK和NF-κB信号通路诱导小鼠肝脏炎症反应的研究.pdf,摘要 氟在环境中普遍存在,是机体必需的微量元素之一。然而,研究发现氟过 量摄入会对机体造成毒性影响,损伤骨骼、牙齿以及肝、肾、脑、睾丸等多个 器官和组织,产生不同程度的病理改变。 本试验以ICR
(CM)。CM作为第二信使,部分激活MAPK,部分激活NF—KB。 核转录因子KB(nuclear factor—kappa B,NF—KB)最初是由sell等从 B细胞核提取物中发现的一种能与免疫球蛋白K轻链基因的增强子KB序 列(GGGACTYFCC)特异结合的核蛋白。可促进轻链基因的表达。后来发 ...
Transcription of miRNA genes in epithelial cells can be elaborately controlled through Toll‐like receptors (TLRs), and associated nuclear factor kappa B (NF‐κB) and mitogen‐activated protein kinase (MAPK) pathways, leading to nuclear transcription factor associated‐transactivation and transrepression...
[13] Qian Y, Zhao Z, Jiang Z, Li X. Role of NF kappa B activator Act1 in CD40-mediated signaling in epithelial cells. Proc. Natl. Acad. Sci. U S A. 2002 Jul 9;99(14):9386-91. PubMed ID: 12089335 [14] Li H, Nord EP. CD40 ligation stimulates MCP-1 and IL-8 production,...
创新点:首次探究了丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)、蛋白激酶B(protein kinase B,AKT)和核因子κB(nuclear factor kappa B,NF-κB)信号通路在温和气单胞菌诱导宿主细胞炎性应答中的作用及相关的分子机制,并分别从正反向进行了研究,围绕NF-κB、MAPK、磷酯酰肌醇-3-激酶(phosphatidylinosi...
The mRNA levels of pro-inflammatory cytokines and NF-κB p65 were determined using qPCR. The expression of relevant proteins was determined using Western blot analysis or immunofluorescence staining. Results: Treatment of SH-SY5Y cells with Fe2+ (50–200 μmol/L) dose-dependently decreased the ...