Immunity, InnateGlycosylation produces a diverse and abundant repertoire of glycans, which are collectively known as the glycome. Glycans are one of the four fundamental macromolecular components of all cells, and are highly regulated in the immune system. Their diversity reflects their multiple ...
Glycosylation of proteins and lipids in mammals is essential for embryogenesis and the development of all tissues. Analyses of glycosylation mutants in cultured mammalian cells and model organisms have been key to defining glycosylation pathways and the
Glycosylation of proteins and lipids in mammals is essential for embryogenesis and the development of all tissues. Analyses of glycosylation mutants in cultured mammalian cells and model organisms have been key to defining glycosylation pathways and the
Glycosylation creates an intricate and complex code for biological information that plays a role in cell-cell communication, infection, and immunity among many biological events. Dynamic changes in the glycosylation status of cells have been observed in tumor cell metastasis and cell differentiation but...
Dysregulated glycosylation plays a major role in disease processes from immune evasion to cognition, sparking research that aims to target glycans for therapeutic benefit. The field is now poised for a boom in drug development. As a harbinger of this activity, glycobiology has already produced ...
BAP encoded an ∼54-kDa protein with an N-terminal endoplasmic reticulum (ER) targeting sequence, two sites of N-linked glycosylation, and a C-terminal ER retention sequence. Immunofluorescence staining demonstrated that BAP co-localized with GRP94 in the endoplasmic reticulum. BAP was ...
Our studies suggest that luminal histamine does affect mucosal and systemic immunity, as well as mammalian epithelial cell signaling pathways. Suppression of IL-6 production within the cecal mucosa is one example of histamine-dependent suppression of gut inflammation in an acute colitis model.34 By ...
More S protein accumulates in ER, suggesting its longer duration for de novo synthesis and glycosylation in ER. While most secretory M-GFP dots co-localize with the staining of E protein, peri-nuclear M-GFP shows two ways, positively and negatively co-localized with E protein. These data ...
H. Methylation-directed glycosylation of chromatin factors represses retrotransposon promoters. Proc. Natl Acad. Sci. USA 117, 14292–14298 (2020). Article CAS PubMed PubMed Central Google Scholar Liu, H., Chang, L. H., Sun, Y., Lu, X. & Stubbs, L. Deep vertebrate roots for ...
H. et al. Novel protein substrates of the phospho-form modification system in Neisseria gonorrhoeae and their connection to O-linked protein glycosylation. Infect. Immun. 80, 22–30 (2012). Article CAS PubMed PubMed Central Google Scholar Olivetta, E. & Federico, M. HIV-1 Nef protects ...