Glycosylation and the immune system. Science,2001,291( 5512) : 2370-2376.Rudd PM, Elliott T, Cresswell P, Wilson IA, Dwek RA (2001) Glycosylation and the immune system. Science 291:2370-2376Rudd PM, Elliot T, Cresswell P, Wilson IA, Dwek RA (2001) Glycosylation and the immune system....
Glycosylation and the immune system. Almost all of the key molecules involved in the innate and adaptive immune response are glycoproteins. In the cellular immune system, specific glycoforms are involved in the folding, quality control, and assembly of peptide-loaded major ... P Rudd,T Elliott,...
Glycosylation and the Immune System complement systemglycosylationoligosaccharidesimmune systemAlmost all of the key molecules involved in the innate and adaptive immune response are glycoproteins. ... PM Rudd,T Elliott,P Cresswell,... - 《Journal of Protein Chemistry》 被引量: 2403发表: 2001年 Memb...
A. Glycosylation and the immune system. Science 291, 2370–2376 (2001). Article ADS CAS PubMed Google Scholar Zhou, J. Y. & Cobb, B. A. Glycans in immunologic health and disease. Annu. Rev. Immunol. 39, 511–536 (2021). Article CAS PubMed Google Scholar Dasari, S. et al. ...
Multiple sclerosis (MS) is a neurodegenerative and autoimmune disorder in which the immune system attacks nerve fibers and myelin in the CNS, interfering with normal signal propagation. Symptoms vary among patients and can include numbness, tingling, memory, cognitive impairment, pain, fatigue, blindne...
and generation of unusual forms of terminal structures arising from sialylation and fucosylation. The functional role of tumor-associated glycans (Tn, sTn, T, and sLea/x) is dependent on the interaction with lectins. Lectins are expressed on the surface of immune cells and endothelial cells or ...
The "danger" model of immunity posits that the immune system is triggered by endogenous danger signals, rather than exogenous non-self signals per se. It has been proposed that danger signals may consist of both intracellular "pre-packed" molecules released from damaged cells and stress-induced ...
Bone homeostasis is assured by a concerted action of bone forming osteoblasts and bone resorbing osteoclasts. This balance can be impaired by the immune system as it is observed in bone destructive autoimmune diseases such as rheumatoid arthritis. However, while cytokine-mediated effects have been ext...
signal transduction pathways (1). Because they can be very large and bulky, oligosaccharides can affect protein–protein interactions by either facilitating or preventing proteins from binding to cognate interaction domains. Because they are hydrophilic, they...
More recently, applications of genome sequencing have revealed the breadth of rare congenital disorders of glycosylation in humans and the influence of genetics on the synthesis of glycans relevant to infectious diseases, cancer progression and diseases of the immune system. This improved understanding ...