Glycosylation and the immune system: P.M. Rudd, T. Elliott, P. Cresswell, et al. Science 291:2370–2376, 2001doi:10.1016/S0887-7963(01)80099-7Sunny DzikTransfusion Medicine Reviews
P.M. Rudd Glycosylation and the immune system Science, 291 (2001), pp. 2370-2376 View in ScopusGoogle Scholar 25 W.H. Yang, et al. An intrinsic mechanism of secreted protein aging and turnover Proc. Natl. Acad. Sci. U. S. A., 112 (2015), pp. 13657-13662 CrossrefView in Scopus...
43,44,45,46,47 Glycosylation not only promotes viral protein folding and subsequent trafficking,45,48,49 but also modulates their interactions with receptors and the following innate and adaptive immune response,50,51,52 which affects the host recognition, viral replication, and infectivity.53,54,...
functions [1,2] Within O-glycosylation, O-GlcNAcylation is unique in terms of the location of the target substrates such as the nucleus, mitochondria and cytosol (Fig.1) [4,5]. O-GlcNAcylation is rather simple but highly dynamic [4,6] by competing reciprocally with phosphorylation and influe...
Glycosylation, the attachment of sugar moieties to proteins, is a post-translational modification (PTM) that provides greater proteomic diversity than other PTMs. Glycosylation is critical for a wide range of biological processes, including cell attachment t...
Glycosylation, the attachment of sugar moieties to proteins, is a post-translational modification (PTM) that provides greater proteomic diversity than other PTMs. Glycosylation is critical for a wide range of biological processes, including cell attachment t...
(tunicamycin) interfere with the process. Glycosylation increases the stability of proteins and may facilitate antigen recognition, appropriate folding, signal transduction, nerve function, etc. It plays an important role in the function of the immune system in the reproductive cell paths and several ...
Multiple sclerosis (MS) is a neurodegenerative and autoimmune disorder in which the immune system attacks nerve fibers and myelin in the CNS, interfering with normal signal propagation. Symptoms vary among patients and can include numbness, tingling, memory, cognitive impairment, pain, fatigue, blindne...
HIV and influenza, two clear threats to human health, have been shown to rely on expression of specific oligosaccharides to evade detection by the host immune system. Additionally, other viruses such as Hendra, SARS-CoV, influenza, hepatitis and West Nile rely on N-linked glycosylation for ...
Specific Complex-type N-Glycans in the Control of T Cell Activation and Autoimmunity Two recent publications demonstrate that specific alterations in N-glycan structure can disable processes in the immune system that keep pathogenic self-recognition at bay. The first (Demetriou et al., 2001) involve...