Coronary artery disease (CAD) is the most common cardiovascular disease (CVD), and previous studies have shown a significant association between N-glycosylation, a highly regulated posttranslational modification, and the development of atherosclerotic plaques. Our aim was to determine whether ...
ACS Cent. Sci.|人IgG亚型在其N-糖基化的结构元件上有所不同 分享一篇发表在ACS Central Science上的文章,标题为 “Human IgG Subclasses Differ in the Structural Elements of TheirN-Glycosylation”, 文章的通讯作者是来自荷兰乌德勒支大学分析化学的Karli R. Reiding助理教授;Karli R. Reiding助理教授专注于糖...
ACS Cent. Sci.|人IgG亚型在其N-糖基化的结构元件上有所不同 分享一篇发表在ACS Central Science上的文章,标题为 “Human IgG Subclasses Differinthe Structural ElementsofTheirN-Glycosylation”, 文章的通讯作者是来自荷兰乌德勒支大学分析化学的Karli R. Reiding助理教授;Karli R. Reiding助理教授专注于糖蛋白质...
14. Zhang, D.; Chen, B.; Wang, Y.; Xia, P.; He, C.; Liu, Y.; Zhang, R.; Zhang, M.; Li, Z., Disease-specific IgG Fc N-glycosylation as personalized biomarkers to differentiate gastric cancer from benign gastric diseases...
图1 IgG N-糖基诊断类风湿性关节炎的ROC曲线图Fig.1 ROC curve of IgG N-glycosylation for diagnosis of rheumatoid arthritisNote: A.ROC plot for the diagnosis of RA with a single glycan-based indicator;B.A graph of the combined diagnosis of RA with a glycosylation index. ...
2021年5月,杨程德主任医师在《RHEUMATOLOGY》杂志在线发表题名为“Characteristics of purified Anti-β2GPI IgG N-glycosylation associate with thrombotic, obstetric, and catastrophic antiphospholipid syndrome.”——抗β2-糖蛋白I I...
Human plasma transferrin (Tf) N-glycosylation has been mostly studied as a marker for congenital disorders of glycosylation, alcohol abuse, and hepatocellular carcinoma. However, inter-individual variability of Tf N-glycosylation is not known, mainly due
(RF)-positive and negative RA patients, as well as anti-citrullinated protein antibodies (ACPA)-positive and negative RA patients. This approach may identify N-glycosylation-associated biomarkers for other autoimmune and infectious diseases and lead to the exploration of promising glycoforms for ...
1983年,Sutton和Phillips 表明N297聚糖对IgG具有强大的结构功能作用。Krapp等(2003年),Yamaguchi等(2006年)Mimura等(2000年)以上研究证实Fc结构域的结构完整性和热稳定性取决于N-聚糖。 1996Lund等发现FcCH2区的其他突变导致半乳糖基化和唾液酸化的增加;α2,3-和α2,6-连接的唾液酸在Fc结构方面不相同,此外,唾液...
Interest in the pathophysiological role of IgG fragment crystallizable (Fc) N-linked glycosylation arose from changes in humoral immune responses. In this study, circulating disease-specific IgG (DSIgG) derived from serum immunoinflammation-related prote