The present invention relates to novel process for the preparation of glycoproteins by mammalian-cell culture wherein the sialic acid content of the glycoprotein' produced is controlled over a broad range of values by manipulating the cell culture environment. The invention provides for processes in ...
Mammalian cell culture is the process of growing mammalian cells in a controlled laboratory environment. These cells are essential for research and development in the life sciences. They allow for the study of complex biological processes in a controlled and reproducible manner. Uses of Mammalian Cel...
The present invention relates to novel process for the preparation of glycoproteins by mammalian cell culture wherein the sialic acid content of the glycoprotein produced is controlled over a broad range of values by manipulating the cell culture environment. The invention provides for processes in ...
Gunther JC, Conner JS, Seborg DE (2007) Fault detection and diagnosis in an industrial fed-batch cell culture process. Biotechnol Prog 23(4):851–857 CAS PubMed Google Scholar Haag JE, Vande Wouwer A, Bogaerts P (2005) Dynamic modelling of complex biological systems: a link between metab...
ell Culture Process Application of a Closed-Loop Analysis Approach to Achieve Process Robustness of a 25,000L Mammalian Cell Culture ProcessApplication of a Closed-Loop Analysis Approach to Achieve Process Robustness of a 25,000L Mammalian Cell Culture ProcessSimpson Gregoire...
Thus, we are distinquishing two aspects of differentiation: (1) the “committment” process, occurring during embryogenesis and resulting in multiple specialized cell types, and (2) regulation of gene expression within a committed cell.This is a preview of subscription content, log in via an ...
cellculturebioreactorMammalian cell cultures have been used for many decades in the manufacture of commercially significant products. These products, predominantly vaccines, have traditionally been produced in small laboratory vessels (i.e., roller bottles, T-flasks, etc.) without significant process ...
展开 关键词: ammonium sulfate precipitation cetyltrimethyl ammonium bromide column chromatography crystallization domiphen bromide ion-exchange resins mammalian cell culture broth process-scale precipitation three-phase partitioning two-phase extraction 出版时间: 2017/03/03 ISBN...
On-line OUR monitoring is easy to implement and is a powerful tool for monitoring the virus infection process. 展开 关键词: MICROCARRIER CELL CULTURE VIRUS PRODUCTION OXYGEN UPTAKE RATE DOI: 10.1016/0141-0229(94)00035-P 被引量: 26 年份: 1995 ...
A framework for real‐time glycosylation monitoring (RT‐GM) in mammalian cell culture 来自 Wiley 喜欢 0 阅读量: 107 摘要: Glycosylation is a critical characteristic of biotherapeutics because of its central role in in vivo efficacy. Multiple factors including medium composition and process conditions...