Malignant plasma cell neoplasms are rarely documented in ferrets. This article reviews the clinical findings for 6 ferrets with histopathologically confirmed malignant cell neoplasia. The most common clinical sign was hind limb ataxia or paresis (5/6), although hyperglobulinemia was identified as the...
Plasma and cerebrospinal fluid population pharmacokinetics of temozolomide in malignant glioma patients Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. Recursive partitioning analysis of prognostic factors in three Radiation Therap...
DNA was isolated from 1 mL serum and plasma using the MagNA Pure LC system. Cell-free DNA was quantified by real-time PCR using the reference gene of the LightCycler t(14;18) kit. Subsequently, the DNA integrity index was calculated as the ratio in relative abundance of 347-bp versus ...
Pancreatic cancer (PAC) remains one of the most lethal malignant neoplasms, which is diagnosed at an advanced stage and thus lose the chance for curative resection. Here, we further probed PAC with a comprehensive multi-omics approach. Using single-cell RNA sequencing, we provided an integrated ...
Five cases were high-grade large cell lymphomas and three cases were of low-grade type. One case of the latter group was associated with elevated IgA in the serum and showed monoclonal reaction of plasmacytic lymphoma cells for kappa light chain and IgA. In this case amyloid deposits were ...
This case illustrates that not all nodular lymphomas are follicular center cell (FCC) neoplasms and that morphological transformation from small round to small cleaved lymphocytes and a corresponding increase in surface immunoglobulins may take place in the follicular mantle zone. The patient had a ...
In addition to primary bone tumors, the advent of bone metastasis represents a critical stage in which numerous malignant neoplasms infiltrate the body. As malignancies progress within osseous tissues, they precipitate diverse complications, such as bone cancer pain and fractures [5]. This review ...
et al. Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms. J. Exp. Med. 212, 1833–1850 (2015). Article CAS PubMed PubMed Central Google Scholar Davidson, I. F. et al. DNA loop extrusion by human cohesin. Science 366, 1338–1345 (2019...
Tumours, or neoplasms (from Greekneo, “new,” andplasma, “formation”), are abnormal growths of cells arising from malfunctions in the regulatory mechanisms that oversee the cells’ growth and development. However, only some types of tumours threatenhealthand life. With few exceptions, that ...
Mutations in the p53 gene are linked to failures in the mechanisms of apoptosis and increased cell proliferation, being common in several human neoplasms [20]. When cells undergo injury and/or errors in DNA replication, p53 becomes phosphorylated. It stops cell cycling to facilitate DNA repair ...