2024年1月18日,复旦中山检验科最新研究成果《Detection of Circulating Plasma Cells in Peripheral Blood Using Deep Learning-Based Morphological Analysis》在国际权威杂志Cancer(IF=6.2,JCR Q1区,Doi:10.1002/cncr.35202)发表。 研究背景 ...
多发性骨髓瘤(multiple myeloma,MM)是一种起源于浆细胞(plasma cells,PCs)的血液系统恶性肿瘤,其特征是骨髓内克隆性浆细胞(clonal plasma cells,cPCs)的异常增殖,至今尚无法根治。 MM主要从两种无症状的前体疾病——意义未明的单克隆丙种球蛋白病(monoclonal gammopathy of undetermined significance,MGUS)和冒烟型多发...
多发性骨髓瘤(multiple myeloma,MM)是一种起源于浆细胞(plasma cells,PCs)的血液系统恶性肿瘤,其特征是骨髓内克隆性浆细胞(clonal plasma cells,cPCs)的异常增殖,至今尚无法根治。 MM主要从两种无症状的前体疾病——意义未明的单克隆丙种球蛋白病(monoclonal gammopathy of undetermined significance,MGUS)和冒烟型多发...
. We also found increasing quantities of plasma cells had a continuous positive association with both increasing inflammation andIFNGexpression while CD8+T-cells, the immune cells more commonly thought to mediate the most tumor immune activity11, did not (Fig.1g). In the setting of increased ...
Cancer cells often become unresponsive to multiple types of therapy. It emerges that these ‘cross-resistant’ tumour cells release lipids that reprogram cells called monocytes to stop them from activating tumour-targeting T cells. Anthony C. Buzzai ...
应用合理的早期治疗方案需要对肿瘤免疫微环境有深入的理解。肿瘤浸润的B细胞和浆细胞(Tumor-infiltrating B and plasma cells (TIBs))能够影响化疗和免疫治疗的反应及预后【1,2】,但已有的单细胞研究缺乏对TIBs在实体肿瘤发病机制中表型...
与空间样本配对的单细胞共有342,749 CD45+ cells,鉴定到的细胞类型有:B cells/plasma cells, T cells, myeloid cells, and mast cells (Figure 3A),细胞亚型分析使用CellTypist。 「B cells/plasma cells亚类」:CD20+ B cell (sc-b0, sc-b2),7 SDC1+ (CD138) plasma cell clusters (Figures 3A and...
It is characterized by abnormal transformation and uncontrolled clonal proliferation of malignant plasma cells in the bone marrow (BM), which can destroy bone structure and inhibit hematopoiesis. Although there are new therapeutic methods, they are not curative, mainly because it is difficult to ...
Cancer metabolism refers to the alterations in cellular metabolism pathways that are evident in cancer cells compared with most normal tissue cells. Metabolic alterations in cancer cells are numerous and include aerobic glycolysis, reduced oxidative phosphorylation and the increased generation of biosynthetic...
Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells DNA methylation is an essential epigenetic mark in mammals. The maintenance of this mark relies on two key proteins: DNMT1 and UHRF1. Here the authors show that, beyond activating DNMT1, UHRF1 has crucial ...