和很多人认为的一样,乳腺癌确实是全世界女性中最常见的恶性肿瘤[1]。 相对来说,男性乳腺癌(male breast cancer,MBC)在临床上比较少见。 男性乳腺癌在男性癌症中占比不足1%[2,3]。在我国,发病率约0.4/10万[4]。 但是,少并不等于不会发生。 最近几年,男性乳腺癌的发病率呈上升趋势[2,3]。 更糟糕的是,...
CANCER susceptibilityGENETIC testingMALE breast cancerBREAST cancerIntroduction: Although hereditary male neoplasms are quite rare, individuals harbouring germline BRCA1/2 pathogenic variants (PVs) may have a risk of developing tumours associated with Hereditary Breast and Ovarian Cance...
The most relevant risk factor for the development of male breast cancer is a mutation in the BRCA2 gene. Most cases present late because of a lack of awareness of the existence of such a malignancy in males and ignorance of the related risk factors. Additionally, males with breast cancer ...
The breast cancer susceptibility gene, BRCA2 on chromosome 13q12–13, was recently isolated1–3. Mutations in BRCA2 are thought to account for as much as 35% of all inherited breast cancer as well as a proportion of inherited ovarian cancer1. Many BRC2-l
Two men had variations in the BRCA2 gene that impairs DNA repair, a common cause of breast cancer in women. Along with an extended study group of 18 additional tumor samples, about 21% of the tumors had 10 to 20 excess copies of the FGFR1 gene, which is linked to treatment-resistant ...
the incidence of this disease, along with the increase in female breast cancer [2]. The genetic susceptibility for the population is the reason for this variability, genetic studies in males however, have shown that germline mutations in BRCA2 alone account for the majority of hereditary breast ...
Male breast cancer. Lancet Occurrence of male breast cancer, a rare disease, peaks at age 71 years. Familial cases usually have BRCA2 rather than BRCA1 mutations. Occupational risks include high temperature environments and exhaust fumes, but electromagnetic field... IS Fentiman,A Fourquet,GN Hort...
Background The contribution of BRCA1 and BRCA2 to the incidence of male breast cancer (MBC) in the United Kingdom is not known, and the importance of these... VM Basham,JM Lipscombe,JM Ward,... - 《Breast Cancer Research》 被引量: 342发表: 2002年 Breast Cancer Risk Among Male BRCA...
BRCA1 gene BRCA2 gene breast augmentation Breast Biopsy breast cancer breast compression breast feeding Breast Implants breast lump breast marker breast mass breast milk breast plastic and reconstructive surgery breast pump breast reconstruction Breast Reduction breast self-examination References in periodicals...
Male breast cancer: the importance of recognizing family history and the preliminary results of linkage analysis to BRCA1 and BRCA2 The aim of the study is to determine the presence of inherited mutations in TP53 in women with early onset breast cancer regardless of their family history and afte...