Seven of the nine disease-associated mutations were detected in the 50 men with breast cancers; for thus in our series, BRCA2 mutations account for 14% of male breast cancer, all but one of which had a family history of male and/or female breast cancer....
The breast cancer susceptibility gene, BRCA2 on chromosome 13q12–13, was recently isolated1–3. Mutations in BRCA2 are thought to account for as much as 35% of all inherited breast cancer as well as a proportion of inherited ovarian cancer1. Many BRC2-l
搜索关键字包括“malebreastcancerriskfactors(男性乳腺癌危险因素)”、“malebreastcancerepidemiology(男性乳腺癌流行病学)”,“malebreastcancergenetics(男性乳腺癌遗传学)”,共涉及34个研究,4865819名患者。 5个研究(N=327667)主要集中在乳腺癌家族史作为男性乳腺癌的一个风险因素。15%-20%的乳腺癌男性有乳腺癌或卵...
男性乳腺癌(male breast cancer,MBC)的发病机制及病因尚不清楚,主要危险因素包括生活方式(肥胖、饮酒、服用雌激素)、职业暴露于高温环境和汽车尾气、疾病情况(睾丸疾病、肝病、胸部放疗等)、遗传因素(Klinefelten综合征、Cowden综合征、乳腺癌家族史及BRCA1/2等基因突变等).其中BRCA2突变明显增加MBC发病风险,BRCA2相关...
BRCA2 PV carriers were at greater risk of developing breast cancer (OR, 5.47) prostate cancer (OR, 1.39), and pancreatic cancer (OR, 3.00). However, they had a significantly lower probability of colorectal cancer (OR, 0.47). "These data will help to optimize medical care in male BRCA1 ...
breast and ovarian cancers in female carriers, and knowledge ofBRCA1/2PVs informs established cancer screening and options for risk reduction. While risks to male carriers ofBRCA1/2PVs are less characterized, there is convincing evidence of increased risk for prostate cancer, pancreatic cancer, and...
Discusses the linkage to BRCA2 region in hereditary male breast cancer. Discovery of BRCA2 gene on chromosome 13q and its function in increasing the risk of breast cancer; Role of endocrine factors in the development of breast cancer; BRCA1 gene on chromosome 17q and its nexus to familial ...
Male breast cancer has been linked extensively to mutations of BRCA2 and, to a lesser extent, BRCA1. The aim of this study was to perform a comprehensive analysis of point mutations and genomic rearrangements in the BRCA1 and BRCA2 genes in 41 men with breast cancer. Deleterious point mutat...
SULT1A1 gene deletion in BRCA2゛ssociated male breast cancer: a link between genes and environmental exposures? Russo A, Tommasi S, Ottini L (2013) SULT1A1 gene deletion in BRCA2-associated male breast cancer: a link between genes and environmental exposures? J... D Palli,P Rizzolo,I ...
21、le breast cancer familiesj.cancer prevention research,2011,4(7):1002-1010.10 ibrahim m,yadav s,ogunleye f,et al.male brca mutation carriers:clinical characteristics and cancer spectrumj.bmc cancer,2018,18(1):179.11 streff h,profato j,ye y,et al.cancer incidence in first-and second-degr...