A good example of this is the use of digoxin in patients with renal insufficiency. In patients with mild to moderate renal insufficiency, the Vdof digoxin is little changed, whereas Cl may be reduced to about one-half to two-thirds normal.15In such patients, the t1/2rises in proportion ...
Starting dose: loading doses of digoxin are generally not required in stable patients with sinus rhythm. A singledailymaintenancedose of 0.25 mg is commonly employed in adults with normal renal function. 初始剂量:在病情稳定伴有窦性心律时,负荷量通常不需要;地高辛浓度在成人肾功能正常者维持量为每日0.2...