A study of single‐dose digoxin kinetics was performed in 6 young and 7 elderly patients. The rate of absorption, determined by the time to peak concentration after an oral dose, was more rapid in the younger group. The extent of absorption, as measured by comparison of the area under the...
The median daily dose was 0.182 mg/day. Digoxin dose was higher than the recommended doses for elderly patients in 75.8% of the patients. CONCLUSION: Our findings show that nearly 40% of elderly patients receive digoxin with inappropriate indications and 75% of these patients take digoxin at ...
The same dose of digoxin resulted in higher blood concentrations and longer blood half-life in the elderly. This is due to the smaller body size and a diminished urinary excretion of digoxin in the elderly. 展开 关键词: Creatinine clearance Renal excretion of digoxin ...
International Journal of Pharmacy PracticeHolden K, Sheldon W, Eavle P, Dawson A, Frator J. Poor correlation between predicted ideal and prescribed digoxin dose: a community-based pharmacokinetic study in the elderly. Int J Pharm Pr`act 2001: 9 (suppl): R23....
Free Essay: Question 1: Digoxin toxicity. Digoxin has a narrow therapeutic index and chronic toxicity is more likely in the elderly and those with renal...
then ¼ the loading dose every 6 to 8 hours twice 5 to 10 years 20 to 45 Adults and pediatric patients over 10 years 10 to 15 2.3 Maintenance Dosing in Adults and Pediatric Patients Over 10 Years Old The maintenance dose is based on lean body weight, renal function, age, and ...
- 《Clinical Pharmacokinetics》 - 2013 - 被引量: 0 Population pharmacokinetics of digoxin after a loading dose in elderly patients P. Mas-Serrano,R. Nalda-Molina,A. Raso,... - International Congress of Therapeutic Drug Monitoring & C...
Administer half the total loading dose initially, then ¼ the loading dose every 6-8 hours twice Adults and pediatric patients over 10 years old 8-12 2.3 Maintenance Dosing in Adults and Pediatric Patients Over 10 Years Old The maintenance dose is based on lean body weight, renal function...
Use digoxin solution to obtain the appropriate dose in infants, young pediatric patients, or patients with very low body weight. Loading Dosing Regimen in Adults and Pediatric Patients For adults and pediatric patients if a loading dosage is to be given, administer half the total loading dose ini...
6 It is important to note that the elderly population, generally having a decreased muscle mass, may show a lower volume of digoxin distribution.25 Protein binding Digoxin protein binding is approximately 25%.25 It is mainly bound to albumin.6 Metabolism About 13% of a digoxin dose is found...