Loading dose of digoxin in renal failure. British Journal of Clinical Pharmacology 1980; 9:593-7.Gault MH, Churchill DN, Kalra J: Loading dose of digoxin in renal failure. Br J Clin Pharmacol 9: 593, 1980Gault, M.H.; Churchill, D.N. and Kalra, J.: Loading dose of digoxin in ...
There is a simple relation between the loading dose (DL) and maintenance dose (DM): because one-half of the total body load is lost in one t1/2, the maintenance dose should be one-half of the loading dose given once every t1/2. This is illustrated inTable 1fordigoxin. It is also ...
Plasma-digoxin concentrations after an intravenous loading dose. Lancet. 1974;2:958.Bertler A, Bergdahl LB, Karlsson E. Plasma digoxin concentrations after an intravenous loading dose. Lancet. 1974; 2: 958Bertler, A.; Bergdahl, B. and Karlsson, E.: Plasma digoxin con- centrations after ...
Healthy dogs were treated once-a-day for 20 days, with a liquid oral dosage form of digoxin (0.022 mg/kg). Serum digoxin concentrations, measured by radio immunoassay technique, were in the therapeutic range 8 h after the second daily dose of digoxin had been administered. Of the ten dogs...
DigoxinInfusionGuinea-pigThe tissue distribution of 12α-[ 3 H]SC-4453 was studied in the guinea-pig after a IS hours infusion at the rate of 4 μg/h/kg, preceded by an IV loading dose. At the end of the infusion, at the steady state, the skeletal muscle apparently presented the...