Keywords Maffamilyproteins;bZipmoti;fMafrecognitionelements;transcriptionfactor 转录因子是起正调控作用的反式作用因子。转 录因子是转录起始过程中RNA聚合酶所需的辅助 因子,真核生物基因在无转录因子时处于不表达状 态。Maf家族蛋白就是细胞核内重要的转录因子, ...
【关键词】Mar家族蛋白;b-Zip基序;Mar识别元件;转录因 子 【中图分类号】R341 MembersandFuctionsoftheMaf Family Proteins YUNChenxia,WUGuang,WANGKun DepartmentofMicrobiology and Immunology,GuangxiTraditionalChineseMedicalUnivenity,Nan- ning,530001,China 【Abstract】 Maf familyproteins area largenumber of tr...
3) Maf family proteins Maf家族蛋白 1. Maf family proteins are a large number of transcriptional factors which include a characteristic basic region and a leucine zipper(b-Zip)motif. Maf家族蛋白是一群结构相似、具有典型的碱性结构域和b-Zip基序的转录因子,可以与细胞核内含有b-Zip基序的其他家族的...
ARK5 is transcriptionally regulated by the Large-MAF family and mediates IGF-1-induced cell invasion in multiple myeloma:Suzuki A,Iida S, Kato-Uranishi M, et al. ARK5 is transcriptionally regulated by the Large-MAF family and mediates IGF-1-induced cell invasion in multiple myeloma: ARK5as...
[193]. Moreover, the small Mafs/Nrf2 heterodimer target gene quinone oxidoreductase-1(NQO1) encodes a protein that directly interacts with HIF-1α and prevents its degradation, which consequently promotes the expression of the VEGF family and angiopoietin [194,195]. The small Mafs/Nrf2 might ...
ARKS, AMP-activated protein kinase (AMPK)-related protein kinase mediating Akt signals, is closely involved in tumor progression, and its stage-associated expression was observed in colorectal cancer. In this study, we found ARKS expression in multiple myeloma cell lines expressing c-MAF and MAFB....
DNA data base search for the Maf-binding consensus sequences suggested that some of the TRE-like cis elements reported previously may actually be the targets for Maf family proteins or their heterodimers with other bZip proteins. 展开 关键词: AGING AUTOFLUORESCENCE CULTURED CELLS MYOCARDIUM LIPOFUSCIN...
Expressed in vitro, the hMAF protein is able to homodimerize in solution and band-shift the NFE2 tandem repeat probe. In addition to homodimers, hMAF can also form high affinity heterodimers with two members of the NFE2/CNC-bZip family (Nrf1 and Nrf2) but not with a third family ...
Importantly, the large Maf-recognizing antiserum demonstrated that a protein(s) in this family binds to Area II control region sequences in intact ॆ cells (Fig. 8). In addition, this antiserum also supershifted the ॆ cell-enriched A/RIPE3b1 complex formed with the B4/5 probe (Fig. ...
(v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog) in CD34+ HPCs from PMF patients.8 MAF belongs to the large-Maf family of transcription factors that act as homo- or heterodimers by binding to the Maf-responsive 1Department of Life Sciences, Centre for Regenerative Medicine 'Stefano...