In a recent study, after stimulation with IFN-γ and/or lipopolysaccharide (LPS), Mao et al. discovered that citrulline levels in macrophages quickly dropped, a phenomenon necessary for the effective initiation of proinflammatory signaling. On a molecular level, citrulline depletion is triggered by I...
IL-1β was produced mainly by JAWS II dendritic cells, only a concentration of 100 µg/ml B4C 2 induced the production of this cytokine by M0 macrophages. Overall, JAWS II cells produced all analyzed cytokines at a constant level, regardless of the concentration of boron carbide. Fig. 6...
C. Single-cell technologies in hepatology: new insights into liver biology and disease pathogenesis. Nat. Rev. Gartroenterol Hepatol. 17, 457–472 (2020). Google Scholar Ramachandran, P. et al. Resolving the fibrotic niche of human liver cirrhosis at single-cell level. Nature 575, 512–...
The immune response to this basal degree of pathogen invasion at the alveolar level of the lungs remains poorly characterized. To date, we have relied on experimental models of infection, where a large inoculum or a highly virulent strain of a bacterial pathogen is administered into the lungs ...
and is considered a negative feedback regulator of macrophages [70,71]. In addition, IL-10 is one of the significant markers of M2a cells in human and mice [4,7,8,29]. In allergic asthma, IL-10 level is elevated in serum [72], but decreases in bronchoalveolar lavage (BAL), which ...
Tumor-associated macrophages are a critical component of the TME. In general, these macrophages have tumor-promoting functions such as tumor initiation, growth, angiogenesis, metastasis, immunosuppression and resistance to therapy [6]. Elucidating the role of macrophages in tumor biology is crucial as...
macrophages would contribute more to tumor PpIX level than tumor cells themselves and PDT may lead to selective killing of macrophages at the site of treat... S Sharma,A Jajoo,A Dube - 《Journal of Photochemistry & Photobiology B Biology》 被引量: 53发表: 2007年 Selective killing of Leishman...
Much of TRAIL biology has focused on its ability to kill cancer cells. However, low TRAIL concentrations positively associate with CVD in people (Schoppet et al., 2006), suggesting a role that goes beyond that of killing. Indeed, non-apoptotic functions, including stimulation of cell survival...
Cellular metabolism is a complex network that is essential for cellular fitness and consists of catabolic processes (degradation of nutrients, predominantly for metabolite or energy generation in mitochondria) and anabolic processes (use of metabolites for synthesis of cellular structures). In short, tiss...
Macrophages are crucial members of the innate immune response and important regulators. The differentiation and activation of macrophages require the timely regulation of gene expression, which depends on the interaction of a variety of factors, includin