In a recent study, after stimulation with IFN-γ and/or lipopolysaccharide (LPS), Mao et al. discovered that citrulline levels in macrophages quickly dropped, a phenomenon necessary for the effective initiation of proinflammatory signaling. On a molecular level, citrulline depletion is triggered by I...
IL-1β was produced mainly by JAWS II dendritic cells, only a concentration of 100 µg/ml B4C 2 induced the production of this cytokine by M0 macrophages. Overall, JAWS II cells produced all analyzed cytokines at a constant level, regardless of the concentration of boron carbide. Fig. 6...
Liver fibrosis is a dynamic pathological process in which the structure and function of the liver abnormally change due to long-term complex inflammatory reactions and chronic liver injury caused by multiple internal and external factors. Previous studies believed that the activation of hepatic stellate ...
Taken together, the above examples demonstrate that a complex regulatory network exits between transcription factors of miRNAs and lncRNAs that drive macrophage polarization, thereby suggesting their importance as regulatory elements in macrophage biology. 3. Interaction between macrophages and ILCs ILCs in ...
Macrophages are crucial members of the innate immune response and important regulators. The differentiation and activation of macrophages require the timely regulation of gene expression, which depends on the interaction of a variety of factors, includin
and is considered a negative feedback regulator of macrophages [70,71]. In addition, IL-10 is one of the significant markers of M2a cells in human and mice [4,7,8,29]. In allergic asthma, IL-10 level is elevated in serum [72], but decreases in bronchoalveolar lavage (BAL), which ...
The immune response to this basal degree of pathogen invasion at the alveolar level of the lungs remains poorly characterized. To date, we have relied on experimental models of infection, where a large inoculum or a highly virulent strain of a bacterial pathogen is administered into the lungs ...
Here, we applied the property of pathogenic mycobacteria to cause phagosome maturation arrest in infected macrophages as a tool to dissect critical steps in... Fratti,A R. - 《Journal of Cell Biology》 被引量: 913发表: 2001年 Phagosome maturation: aging gracefully. Foreign particles and apoptoti...
C. Single-cell technologies in hepatology: new insights into liver biology and disease pathogenesis. Nat. Rev. Gartroenterol Hepatol. 17, 457–472 (2020). Google Scholar Ramachandran, P. et al. Resolving the fibrotic niche of human liver cirrhosis at single-cell level. Nature 575, 512–...
A conventional paradigm of rBMAT biology is that its adipocytes are strikingly dynamic and that their mass increases with diet-induced obesity, steroid treatment, alcohol drinking, or ageing22. However, we have uncovered an unusual alteration of the rBMAT depot that contrasts with the conventional ...