RXR deficiency leads to lipid accumulation and apoptosis of adult LPMs Oil-red staining revealed a higher abundance of lipid-filled vacuoles in RXR-deficient peritoneal TIM4+ LPMs than in wild-type TIM4+ LPMs (Fig. 4a). Increased lipid accumulation was not due to increased uptake, since RXR-...
Electron-microscopic examination revealed macrophages abutting lipocytes and containing lipid droplets, clear vacuoles and lysosomes in varying proportions. Lipocytes varied in size. The lipid appeared normal in most, but scattered cells contained electron-dense granules or needle-shaped clefts within the ...
and LPS (orange).jRNA sequence showing changes in M1/M2 markers of MDMs after rA8 stimulation.kHepatocytes were cocultured with MDMs and treated with rA8 and PA, after which they were stained for lipid droplets (Oil Red O; scale bar, 100 µm) and apoptosis (TUNEL, highlighted by y...
Local activation of normally quiescent tissue macrophages may provoke rearrangements of their surface receptors, making them more sensitive to nanoparticle recognition, and leading to abnormally increased internalization rates in phagosomes—cellular vacuoles containing phagocytosed material. Increased clearance ...
B: Lipid accumulation in cholesterol storage vacuoles induced by incubation with 50 μg/ml of oxLDL for 48 hours revealed by Nile Red staining. C: Reduction of foam cell formation in vitro induced by incubation with oxLDL (50 μg/ml) for 48 hours of MDMs reseeded on immobilized anti-α...
Interiorized plasma membranes were also prepared without exposure to glutaraldehyde from phagocytic vacuoles recovered from alveolar macrophages which had ingested large numbers of polystyrene spheres. These membranes were contaminated with lysosomal constituents, but they were nevertheless of value for ...
lipid vacuolesfoam cellsThe morphologica[ basis of atherosclerotic plaques is formed by foam cells (FC) and connective tissue, Transformation of ceils of the vessel wall into FC is observed at sites of its infiltration by apo-B-conta~ning lipoproteins. It is well known, however, that ...
This disease is characterized by fat accumulation in the form of micro and macrovacuoles of lipids in hepatocytes [2] and may progress from simple steatosis, non-alcoholic steatohepatitis to fibrosis, advanced cirrhosis and hepatocarcinoma [3]. However, its pathophysiology has not yet been fully ...
IRG and GBP Host Resistance Factors Target Aberrant, "Non-self" Vacuoles Characterized by the Missing of "Self" IRGM Proteins Interferon-inducible GTPases of the Immunity Related GTPase (IRG) and Guanylate Binding Protein (GBP) families provide resistance to intracellular pathogen... AK Haldar,HA...
Notably, extensive lipid infiltration appeared in liver tissue was observed in the NAFLD mouse model. HE staining of the HFHSD group showed the presence of liver lipid vacuoles, Masson staining revealed liver tissue fibrosis around the hepatic sinuses in mice, and Oil Red O staining revealed the...