Depending on their resident tissue, macrophages are exposed to highly diverse metabolic environments. Adapted to their niche, they can contribute to local metabolic turnover through metabolite uptake, conversion, storage and release. Disturbances in tissue homeostasis caused by infection, inflammation or ...
Scavenging Lipid Oxidation Products Improves Intestinal Inflammation and Integrity After Renal Injurydoi:10.1681/ASN.20223311S1592dJianyong ZhongHaichun YangSean S. DaviesValentina KonAmerican Society of NephrologyJournal of the American Society of Nephrology...
Type 2 diabetes mellitus (T2DM) is an endocrine metabolic disorder characterized by dysfunctional pancreatic β-cells and peripheral insulin resistance, resulting in abnormalities of glucose metabolism, dyslipidemia, and chronic inflammation [1]. T2DM is commonly associated with poor blood glucose control,...
Lipid peroxidesand activated macrophages play a crucial role in arthritis and other inflammatory diseases. Bothin vitroandin vivoanimal experiments have documented the anti-inflammatory potential of spice principles suxh as curcumin, capsaicin, and eugenol. Turmeric happens to be the earliest anti-inflam...
The loss of FABP5 causes macrophages to accumulate more free long-chain unsaturated fatty acids, which further enhances FAO and oxidative phosphorylation. It also activates PPAR-γ signaling, which together promote macrophage M2 polarization and aggravate allergic airway inflammation [20]. Cancer-...
potentially providing a controllable and versatile platform. In addition to maintaining lipid metabolism, LDs also play a crucial role in cellular signaling and inflammation [92,93]. LD-based systems could be further expanded by combining them with other therapeutic modalities, such as chemotherapy and...
Up-regulation of xCT also has been demonstrated in other cancers in including lymphomas [52], and gliomas [53, 54]. CD44v has recently been shown to involved in the scavenging of ROS via the stabilization of xCT protein at the cellular membrane, thus activation of CD44v-xCT-GSH axis play...
Cancer stem cells (CSCs) or tumor-initiating cells (TICs) represent a small population of cancer cells with self-renewal and tumor-initiating properties. Unlike the bulk of tumor cells, CSCs or TICs are refractory to traditional therapy and are responsib
Figure 1. The TGR5 Agonist INT-777 Inhibits Macrophage Inflammation (A) cAMP induction in primary macrophages isolated from Tgr5−/− and Tgr5+/+ mice measured 1 hr after stimulation with vehicle (white bars) or 3 μM INT-777 (black bars; n = 3). (B) Intracellular calcium flux in ...
Myeloperoxidase a heme oxidase found in inflammatory cells such as macrophages and neutrophils. It catalyzes the production of hypochlorous acid (HOCl) via a reaction between hydrogen peroxide and chloride molecule. HOCl is a primary oxidant that causes the oxidation of LDL molecule (Hazen and H...