3. Metabolic features of lipid scavenging macrophages 4. Lipids in inflammatory responses of macrophages 5. Lipid scavenging macrophages across different tissues 6. Future perspectives and open questions Declar
Lipid peroxide refers to toxic compounds generated from the excessive peroxidation of lipids, which can disrupt normal cell membrane functions and contribute to various pathological processes like inflammation, cancer, and neurodegenerative diseases.
Scavenging Lipid Oxidation Products Improves Intestinal Inflammation and Integrity After Renal Injurydoi:10.1681/ASN.20223311S1592dJianyong ZhongHaichun YangSean S. DaviesValentina KonAmerican Society of NephrologyJournal of the American Society of Nephrology...
In addition, 4-HNE has a role in numerous cell processes, including but not limited to oxidative stress [66], inflammation [67], cell proliferation [68] and cell death [69]. MDA is usually used as a biomarker for lipid peroxidation assessment [44]. Moreover, MDA can react with amino ...
These lipids and their metabolites participate 86 in and regulate multiple metabolic and signaling pathways within the cell and in the 87 extracellular space, thereby affecting major cancer hallmarks, including cell growth, 88 proliferation, metabolism, migration, inflammation, and immunity (Attané and ...
integral to multiple processes, including cellular signaling, energy storage, inflammation, and immune responses. Dysregulated lipid metabolism has been observed in various tumors, including breast, liver, and colon. Altered lipid metabolism plays a critical role in tumor initiation, progression, and ...
Such accumulation leads to inflammation induced by tubulointerstitial fibrosis, glomerular plasma membrane hypertrophy and dilatation, thickening of the glomerular basement membrane, loss of podocyte foot processes, and infiltration of monocytes and macrophages [3]. Disorders of lipid metabolism are associated...
COX-2 is an important component of inflammation, associated with pro-inflammatory activity, responsible for the production of prostaglandin E289. In the present work, the lipid extracts ofChlorococcum amblystomatisexhibit a COX-2 inhibiting activity. It is the first time that such a response has ...
Other flavonoids, such as melitidin, neoeriocitrin, and rutin, have been shown to inhibit LDL-C oxidation and to inhibit cholesterol triglyceride synthesis via AMPK [26]. These flavonoids may potentially have anti-atherosclerotic properties through radical-scavenging activity [16]. BPF may also ...
In a similar fashion, conditions of acute phase and inflammation involve an enlarged pool of triglyceride-rich lipoproteins. Therefore, similar alterations to the HDL lipid core are typically observed in the acute phase and during inflammation (94, 116). Thus, acute-phase HDL obtained from patients...