3. Metabolic features of lipid scavenging macrophages 4. Lipids in inflammatory responses of macrophages 5. Lipid scavenging macrophages across different tissues 6. Future perspectives and open questions Declaration of competing interest Acknowledgments ReferencesShow full outline Cited by (39) Figures (2...
OLE efficacy was preserved within NLC-OLE ameliorating inflammation in a murine model of acute colitis: reduced levels of TNF-伪 and IL-6, decreased neutrophil infiltration and improved histopathology of the colon were reported. In addition, NLC-OLE enhanced the ROS scavenging activity of OLE in ...
In addition, 4-HNE has a role in numerous cell processes, including but not limited to oxidative stress [66], inflammation [67], cell proliferation [68] and cell death [69]. MDA is usually used as a biomarker for lipid peroxidation assessment [44]. Moreover, MDA can react with amino ...
FAs are a crucial energy source for various cellular processes, and they serve as the structural backbone of phospholipids and glycolipids in cell membranes [69]. There is a strong correlation between inflammation, metabolic syndrome, and increased consumption of saturated fatty acids (SFAs), particul...
[76]. It emerged as a distinct cell death program due to the activation of caspase 1 and caspase 11-dependent inflammasomes in macrophages infected withSalmonella[116,117]. Next, the cleavage of GSDMD (gasdermin D) by caspase 1 and caspase 11 to produce the N-terminal fragment of GSDMD (...
Acquisition of a lipid-laden phenotype by immune cells has been defined in infectious diseases and atherosclerosis but remains largely uncharacterized in cancer. Here, in breast cancer models, we found that neutrophils are induced to accumulate neutral lipids upon interaction with resident mesenchymal cel...
Sphingolipids are bioactive lipids that regulate cellular processes such as cell differentiation, proliferation, apoptosis, and inflammation. Sphingolipids can be obtained either by diet or de novo synthesis [215]. However, it has been reported recently that the commensal gut microbiota (Bacteroides,Pre...
and communication between macrophages and other innate immune cells. Overall, this may facilitate the activity of an already in-alert-state immune system, thereby increasing the likelihood of an autoimmune response, and leading recruitment of CD8+ and/or NK cells to the pancreatic islets. Ultimately...
Lipid peroxide refers to toxic compounds generated from the excessive peroxidation of lipids, which can disrupt normal cell membrane functions and contribute to various pathological processes like inflammation, cancer, and neurodegenerative diseases.
Other flavonoids, such as melitidin, neoeriocitrin, and rutin, have been shown to inhibit LDL-C oxidation and to inhibit cholesterol triglyceride synthesis via AMPK [26]. These flavonoids may potentially have anti-atherosclerotic properties through radical-scavenging activity [16]. BPF may also ...