2024年8月12日,来自荷兰癌症研究所的Leila Akkar团队在Cell杂志上发表了一篇题为“Macrophage-mediated myelin recycling fuels brain cancer malignancy”的文章。论文就在胶质母细胞瘤中找到了一群非常特殊的巨噬细胞-lipid-laden macrophages (LLMs),它们非常喜欢摄取脂质。巨噬细胞收集这些脂质并非为了增殖,而是在代谢...
The presence of lipids in alveolar macrophages (AMs) may impair their phagocytic response, and determine airway inflammation and obstruction. To determine the factors such as severity of asthma, chronic cough, airway inflammation and obesity that may influence the presence of lipids in lung ...
Lipid-laden macrophage index in healthy canines Background鈥 The quantity of lipids in alveolar macrophages is used clinically as an indicator of aspiration, which is associated with increased lung infla... O.,Savchenko,A.,... - 《European Journal of Clinical Investigation》 被引量: 5发表: 20...
Cancer-associated fibroblasts secrete colony-stimulating factor 1 (CSF-1) to increase the ROS content in monocytes, which induces an M2-type differentiation of macrophages. The upregulation of FASN in specific mouse TAM subsets due to the secretion of CSF1 by cancer cells supports in vivo lung ...
Silicosis is a common occupational disease and represents a significant contributor to respiratory morbidity and mortality worldwide. Lipid-laden macrophages, or foam cells, are observed in the lungs of patients with silicosis but the mechanisms mediatin
Lipid-laden macrophages (LLM) in tracheal aspirates are reported to be pathognomonic findings in exo- and endogenous lipoid pneumonia in adults. A pilot study was carried out to evaluate the effect of lipid infusion on the LLM index of the tracheal aspirates from ventilated neonates. All intu...
We conclude that (1) the mere presence of lipid-laden alveolar macrophages in lower respiratory secretions is a nonspecific marker of parenchymal lung disease; (2) the computation of a lipid-laden alveolar macrophage index may be helpful in excluding aspiration as a cause of parenchymal lung ...
The presence of lipids in alveolar macrophages (AMs) may impair their phagocytic response, and determine airway inflammation and obstruction. To determine the factors such as severity of asthma, chronic cough, airway inflammation and obesity that may influence the presence of lipids in lung macrophages...
We evaluated bronchoalveolar lavage fluid (BALF) from 68 children aged 6 months to 14 years (median 3.75 years) for the presence of lipid-laden alveolar macrophages. We compared children with chronic chest disease (CCD) and GER to healthy surgical controls without known lung disease, and to ...
Lipid-laden foamy macrophages are characteristic of xanthogranulomatous pyelonephritis (XGP). We have encountered a case of renal cell carcinoma (RCC), with extensive necrosis, in which confluent sheets of foamy macrophages were a dominant feature. We describe the case and discuss the potential froze...