L. et al. Lineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cells. Science 351, aad5510 (2016). Article PubMed PubMed Central Google Scholar Bleriot, C. et al. Liver-resident macrophage necroptosis orchestrates type 1 microbicidal inflammation and type-2-...
Twenty-four hours later, protein levels of α-collagen I, angiotensin II type 1 receptor (AT1R), transforming growth factor-β (TGF-β), and phospho-Smad2/3 (p-Smad2/3) in lung fibroblasts were examined. The Student's t test or analysis of variance were used for statistical analysis....
Myeloid A20 deficiency induces strong classical macrophage polarization which impedes anti-helminth type-2 immune activation; however, it promotes detrimental Th1/Th17 responses. Antibody-mediated neutralization of the type-1 cytokines IFN-γ, IL-18, and IL-12 prevents myeloid-orchestrated Th1 ...
A cell type that was classically considered to be activated by Interferon-c, under the influence of T(H)-1 type of response and a well-accepted warrior of cellular immunity to the intracellular pathogens is not as simple as once considered. Past decade has revolutionized this notion with the...
external or environmental stimuli for specific type of activation and function. Macrophages play essential roles in both immune responses and tissue homeostasis in a manner depending on environmental cues5. Roughly, macrophages can be classified into two functional types termed M1 (proinflammatory or ...
As its production is related to the state of immunity, MIF was considered to be a molecular equivalent of the delayed type hypersensitive (DTH) state. By chemical characterization it became clear that MIF activity was associated with a group of molecules, whose molecular weight ranged from below...
Yanagita M,Kobayashi R,Murakami S. Nicotine can skew the characterization of the macrophage type-1 (MPhi1) phenotype differentiated with granulocyte-macrophage colony-stimulating factor to the MPhi2 phenotype.[J].Biochemical and Biophysical Research Communications 2009,1(1)....
Involvement of both the V2 and V3 Regions of the CCR5-Tropic Human Immunodeficiency Virus Type 1 Envelope in Reduced Sensitivity to Macrophage Inflammatory... 2000. Involvement of both the V2 and V3 regions of the CCR5- tropic human immunodeficiency virus type 1 envelope in reduced sensitivity to...
DENV replication in monocytes may also be suppressed by NK cell activation through a TRAIL-dependent mechanism augmented by type I IFNs [36]. On the other hand, monocyte-derived dermal macrophages bind and internalize DENV into early phagosomes but do not permit virus replication and may ...
Adoptive cell therapy with chimeric antigen receptor (CAR) immunotherapy has made tremendous progress with five CAR T therapies approved by the US Food and Drug Administration for hematological malignancies. However, CAR immunotherapy in solid tumors lags significantly behind. Some of the major hurdles ...