TNF-α levels were also increased in the culture medium of M1 macrophages. M0 and M2 macrophages or their supernatants did not significantly stimulate calcification in VSMCs. Following transfection with anti-CA1 or CA2 siRNAs, β-GP-induced VSMCs showed decreased calcification, but th...
Inflammatory bowel disease (IBD) is a chronic disease in which macrophages play an important role in its pathogenesis. Platelet-derived growth factor-BB (PDGF-BB) secreted by macrophages is involved in the repair of vascular endothelial injury during inflammatory reactions. Methods The expression level...
In this work, based on the highly enriched characteristics of M1 type macrophages in local inflammation, we used exosomes derived from bone marrow mesenchymal stem cells (BMSC) as drug carriers, modified with hyaluronic acid (HA) and polyethylene glycol (PEG) to prepare an inflammation targeted ...
Tumor-Targeted Drug and Cpg Delivery System for Phototherapy and Docetaxel-Enhanced Immunotherapy with Polarization toward M1-Type Macrophages on Triple Negative Breast Cancers类型: 作者:Chen, L., Zhou, L., Wang, C., Han, Y., Lu, Y., Liu, J., Hu, X., Yao, T., Lin, Y., Liang, ...
Fruquintinib inhibits VEGF/VEGFR2 axis of choroidal endothelial cells and M1-type macrophages to protect against mouse laser-induced choroidal neovascularization Xiaojuan Liu, Aisong Guo, Yuanyuan Tu, Wendie Li, Lele Li, Wangrui Liu, Yuanyuan Ju, Yamei Zhou, Aimin Sang & Manhui ...
Nanoparticle-based photothermal therapy offers a potential solution, as it can achieve thermal ablation of tumors through photothermal conversion, modulate cytokine and exosome secretion from macrophages to assist in treatment. Herein, a system that integrates gold-manganese nanomaterials and engineered ...
The study aims to explore the medical prospect of melatonin (MLT) and the underlying therapeutic mechanism of MLT-mediated macrophage (Mφ) polarization on the function of nucleus pulposus (NP) in intervertebral disc degeneration (IDD). RAW 264.7 Mφs we
Obesity and insulin resistance are closely associated with a state of low-grade inflammation in the body, and adipose tissue macrophages (ATMs) play central roles in this inflammation. ATMs are known to exhibit marked functional heterogeneity. M1 ATMs produce inflammatory cytokines and induce insulin ...
Methods(1) The primary peritoneal macrophages in mice induced by 3% thiglycollate broth were divided into three groups: control group, CD137 signaling activated group and CD137 signaling inhibited group. Various specific markers of M1 and M2 macrophages were detected to observe the phenotype change...
In contrast here to avoid potential contributions made by lymphocytes, endothelial cells, macrophages, and local stromal elements, we exploited 3D mammary epithelial cell cultures where the formation of self-organized acini structures recapitulates those normally observed during mammary gland organogenesis. ...