IFN-gamma-mediated A2bR blockade leads to a prolonged production of TNF-alpha and IL-12 in response to TLR ligation. The pharmacologic inhibition or the genetic deletion of the A2bR results in a hyperinflammatory response to TLR ligation, similar to IFN-gamma treatment of macrophages. Conversely...
Macrophage inflammatory protein 1 alpha (MIP-1 alpha) is a member of the C-C subfamily of chemokines, a large superfamily of low-molecular weight, inducibl... DN Cook - 《Journal of Leukocyte Biology》 被引量: 456发表: 1996年 Antisense inhibition of macrophage inflammatory protein 1-α bloc...
巨噬细胞根据功能及炎症因子分泌水平分为M1型巨噬细胞及M2型巨噬细胞两种亚群。M1巨噬细胞（经典激活巨噬细胞），主要由LPS及IFNγ激活，分泌高水平的IL2及较低水平的IL10，主要起到促进炎症发生发展，杀菌及吞噬等作用。而M2巨噬细胞（交替激活巨噬细胞）主要由IL4炎症因子激活，主要通过分泌IL10等抗...
Interleukin(IL) -12 is a logical candidate for participation in the differentiation of T helper (Th) 1 cells. IL-12 is produced by macrophages and B cells and induces the production of interferon (IFN) -γ from Th1 cells and NK cells. In this study. we show that the IFN-γ itself is...
Interferon-gamma (IFN-gamma) and interleukin-6 (IL-6) in peritoneal fluid and macrophage- conditioned media of women with endometriosis. Am J Reprod Immunol 1994;32:180-3.Keenan A, Chen TT, Chadwell NL, Torry DS, Caudle MR. Interferon- gamma (IFN-g) and interleukin-6 (IL-6) in ...
Rheumatoid arthritis (RA) is a chronic and inflammatory autoimmune disease. Macrophage pyroptosis, a proinflammatory form of cell death, is critically important in RA; however, the detailed mechanism underlying pyroptosis induction is not yet well unders
(I-A/I-E) on the surfaces of resident peritoneal macrophages (rpMφ) of lupus and normal mice, (2) spontaneous and lectin-induced in vitro production of Mφ-stimulating factors (interferon, IFN; Mφ-activating factor, MAF; Mφ-Ia-inducing/recruiting factor, MIRF), and (3) responses of...
a regulator role for the bacterial component LPS in RMs, but not AGMs, whereas interferon-γ (IFN-γ) and interferon-α (IFN-α) type interferons had similarp-values for the two model systems. The AGM response showed stronger enrichment for interferon-λ (IFN-λ), a potent antiviral ...
Interferon (IFN)-γ, a key immunoregulatory cytokine, has been thought to be produced solely by activated T cells and natural killer cells. In this study, we show that murine bone marrow– derived macrophages (BMMΦ) secrete large amounts of IFN-γ upon appropriate stimulation. Although interle...
Repairing bone defects is a complex cascade reaction process, as immune system regulation, vascular growth, and osteogenic differentiation are essential. Thus, developing a tissue-engineered biomaterial that caters to the complex healing process of bone