IFN-gamma-mediated A2bR blockade leads to a prolonged production of TNF-alpha and IL-12 in response to TLR ligation. The pharmacologic inhibition or the genetic deletion of the A2bR results in a hyperinflammatory response to TLR ligation, similar to IFN-gamma treatment of macrophages. Conversely...
巨噬细胞根据功能及炎症因子分泌水平分为M1型巨噬细胞及M2型巨噬细胞两种亚群。M1巨噬细胞（经典激活巨噬细胞），主要由LPS及IFNγ激活，分泌高水平的IL2及较低水平的IL10，主要起到促进炎症发生发展，杀菌及吞噬等作用。而M2巨噬细胞（交替激活巨噬细胞）主要由IL4炎症因子激活，主要通过分泌IL10等抗...
IFN-γ-induced macrophage antileishmanial mechanisms in mice: A role for immunity-related GTPases, Irgm1 and Irgm3, in Leishmania donovani infection in the... In C57BL/6 mice, Leishmania donovani infection in the liver provoked IFN-γ-induced expression of the immunity-related GTPases (...
Rheumatoid arthritis (RA) is a chronic and inflammatory autoimmune disease. Macrophage pyroptosis, a proinflammatory form of cell death, is critically important in RA; however, the detailed mechanism underlying pyroptosis induction is not yet well understood. Here, we report that DNA polymerase β (P...
A. Campbell. 1994. TNF-alpha and IFN-gamma stimulate a macrophage precursor cell line to kill Listeria monocytogenes in a nitric oxide-independent manner... PJ Leenen,BP Canono,DA Drevets,... - 《Journal of Immunology》 被引量: 136发表: 1994年 Inhibition of the multiplication of Listeria...
Exosomes mediate the cell-to-cell transmission of ifn-alpha-induced antiviral activity. Nat Immunol. 2013;14(8):793–803. Article CAS Google Scholar Wang X, Luo G, Zhang K, Cao J, Huang C, Jiang T, et al. Hypoxic tumor-derived exosomal mir-301a mediates m2 macrophage polarization via...
Severe Acute Respiratory Syndrome (SARS) is a severe respiratory illness caused by a novel virus, the SARS coronavirus (SARS-CoV). 3C-like protease (3CLpro) of SARS-CoV plays a role in processing viral polypeptide precursors and is responsible of viral maturation. However, the function of 3...
2013). Nevertheless, also IFN-γ-dependent pathways reduce TfR-dependent iron uptake and promote iron efflux via FPN (Nairz et al. 2008) as a strategy to avoid intracellular bacterial growth. Contrarily, growth of other intracellular pathogens such as Leishmania could be promoted by iron ...
IFN-gamma inhibited granulocyte colony-stimulating factor (G-CSF)- and interleukin-3 (IL-3)-dependent colony growth by granulocyte-macrophage (GM) progenitors derived from the bone marrow cells of normal mice. However, the number of IL-3-dependent GM colonies formed by the bone marrow cells ...
Repairing bone defects is a complex cascade reaction process, as immune system regulation, vascular growth, and osteogenic differentiation are essential. Thus, developing a tissue-engineered biomaterial that caters to the complex healing process of bone