IFN-gamma-mediated A2bR blockade leads to a prolonged production of TNF-alpha and IL-12 in response to TLR ligation. The pharmacologic inhibition or the genetic deletion of the A2bR results in a hyperinflammatory response to TLR ligation, similar to IFN-gamma treatment of macrophages. Conversely...
Interleukin(IL) -12 is a logical candidate for participation in the differentiation of T helper (Th) 1 cells. IL-12 is produced by macrophages and B cells and induces the production of interferon (IFN) -γ from Th1 cells and NK cells. In this study. we show that the IFN-γ itself is...
巨噬细胞根据功能及炎症因子分泌水平分为M1型巨噬细胞及M2型巨噬细胞两种亚群。M1巨噬细胞（经典激活巨噬细胞），主要由LPS及IFNγ激活，分泌高水平的IL2及较低水平的IL10，主要起到促进炎症发生发展，杀菌及吞噬等作用。而M2巨噬细胞（交替激活巨噬细胞）主要由IL4炎症因子激活，主要通过分泌IL10等抗...
Macrophage activation syndrome: characteristic findings on liver biopsy illustrating the key role of activated, IFN-γ-producing lymphocytes and IL-6- and TNF-α-producing macrophages. Blood. 2005;105(4):1648–51. Article CAS PubMed Google Scholar Ravelli A, Davì S, Minoia F, Martini A, ...
(I-A/I-E) on the surfaces of resident peritoneal macrophages (rpMφ) of lupus and normal mice, (2) spontaneous and lectin-induced in vitro production of Mφ-stimulating factors (interferon, IFN; Mφ-activating factor, MAF; Mφ-Ia-inducing/recruiting factor, MIRF), and (3) responses of...
Rheumatoid arthritis (RA) is a chronic and inflammatory autoimmune disease. Macrophage pyroptosis, a proinflammatory form of cell death, is critically important in RA; however, the detailed mechanism underlying pyroptosis induction is not yet well understood. Here, we report that DNA polymerase β (...
Gpnmb is induced in macrophages by IFN-γ and lipopolysaccharide and acts as a feedback regulator of proinflammatory responses. J Immunol. 2007;178:6557–66. Article CAS PubMed Google Scholar Yu B, Alboslemy T, Safadi F, Kim MH. Glycoprotein Nonmelanoma Clone B Regulates the Crosstalk ...
Jeffrey A. KeenanThomas T. ChenNancy L. ChadwellDonald S. TorryMichael R. CaudleAmerican Journal of Reproductive ImmunologyKeenan JA, Chen TT, Chadwell NL, Torry DS, Caudle MR. Interferon-gamma (IFN-gamma) and interleukin-6 (IL-6) in peritoneal fluid and macrophage-conditioned media of ...
TLR2-dependent inhibition of macrophage responses to IFN-gamma is mediated by distinct, gene-specific mechanisms. PLoS ONE. 2009;4(7): e6329. Article PubMed PubMed Central Google Scholar Heise CE, Pahuja A, Hudson SC, Mistry MS, Putnam AL, Gross MM, et al. Pharmacological characterization...
Interferon (IFN)-γ, a key immunoregulatory cytokine, has been thought to be produced solely by activated T cells and natural killer cells. In this study, we show that murine bone marrow– derived macrophages (BMMΦ) secrete large amounts of IFN-γ upon appropriate stimulation. Although interle...