Interferon-gamma (IFN-gamma) is a potent activator of macrophages capable of synergizing with pro-inflammatory pathways to enhance macrophage response to activating stimuli. Our laboratory has demonstrated that a major mechanism by which IFN-gamma primes macrophages for enhanced immune responses is ...
Tumor growth inhibited by ERK1/2 inhibitor through stimulating expression of macrophage interferon gamma本发明涉及一种治疗肿瘤的新方法. The present invention relates to a novel method for treating tumors. IFNγ是抗病毒,抗肿瘤的重要细胞因子,LXR是配体激活转录分子,ERK1/2抑制剂是进行临床II期实验的治疗...
The timing of tnf and ifn-gamma signaling affects macrophage activation strategies during mycobacterium tuberculosis infection. J Theor Biol. 2008; 252 (1):24–38.Ray JC, Wang J, Chan J, Kirschner DE (2008) The timing of TNF and IFN-gamma signaling affects macrophage activation strategies ...
IFN-gamma Primes Macrophage Activation by Increasing Phosphatase and Tensin Homolog via Downregulation of miR-3473b IFN-γ primes macrophage activation by increasing Phosphatase and Tensin homolog via Downregulation of miR-3473b. J Immunol. 2014;193:3036-44... Yiquan,Xue,Qiuyan,... - 《Journal of...
Activation of macrophage proinflammatory and antimicrobial phenotypes is regulated by IFN-γ and LPS via synergistic induction of canonical, inflammatory NF-κB target genes. However, whether IFN-γ negatively regulates components of the LPS response, an
Besides the established role of interleukin-12 (IL-12) and IL-18 on interferon-gamma (IFN-gamma) production by natural killer (NK), T, and B cells, the effects of these cytokines on macrophages are largely unknown. Here, we investigated the role of IL-12/IL-18 on nitric oxide (NO) ...
1A murine macrophage cell line, J774, expressed nitric oxide (NO) synthase activity in response to interferon-gamma (IFN-, 10 u ml1) plus lipopolysaccharid... J Assreuy,FQ Cunha,FY Liew,... - 《Br J Pharmacol》 被引量: 780发表: 1993年 IL-15 is a novel growth factor for murine ...
IFN-gamma and TNF regulate macrophage expression of the chemotactic S100 protein S100A8. The murine calcium-binding protein S100A8 is a potent chemoattractant for neutrophils and monocytes in vivo and in vitro but may also play a protective rol... K Xu,CL Geczy - 《Journal of Immunology》 被...
MACROPHAGE CANDIDACIDAL ACTIVITY IN HUMAN NEONATES: DECREASED SENSNIVITY TO MODULATION BY IFN-|[gamma]|In an attempt to understand the mechanisms of host defense in the term neonate against candida, we studied interaction between Calbicans and monocyte-derived macrophages (MDM) cultured for 5 days...
Keenan JA, Chen TT, Chadwell NL, Torry DS, Caudle MR (1994) Interferon-gamma (IFN-gamma) and interleukin-6 (IL-6) in peritoneal fluid and macrophage-conditioned media of women with endometriosis. Am J Reprod Immunol 32:180-183Keenan, J. A., Chen, T. T., Chadwell, N. L., ...