Behrens EM. Macrophage activation syndrome in rheumatic disease: What is the role of the antigen presenting cell? Autoimmun Rev 2008;7:305-8.Behrens EM. Macrophage activation syndrome in rheumatic disease: what is the role of the antigen presenting cell? Autoimmun Rev 2008;7:305-8....
We asked whether, as in humans, a population of antigen-presenting macrophages infiltrates the epidermis of ultraviolet (UV)-exposed BALB/c mice. Using three-color flow cytometry on cell suspensions plus in situ immunofluorescence microscopy, the phenotype of normal Langerhans cells was class II majo...
The clearance of immunosuppressive TAMs already present in the TME is another option to alleviate immunotherapy resistance. A feasible method might be employing cytotoxic T cells to deplete TAMs. CAR-T-cell therapy, which can specifically recognize and eliminate cells expressing specific antigens, has ...
Cells isolated in the fluorescence-activated cell sorter with anti-Ig reagents also showed an antigen-presenting function. We raise the question whether our results imply an antigen-presenting function of B cells... Gary,M.,Kammer,... - 《Clinical Immunology & Immunopathology》 被引量: 96发表...
Macrophages also function in the presentation of antigens to T cells, as well as in the induction of expression of co-stimulatory molecules on other antigen-presenting cell types, which initiates the adaptive immune response [1]. Furthermore they play an important role...
Splenic adherent cells incubated overnight with SRBC plus GM-CSF were also more efficient antigen-presenting cells than splenic adherent cells incubated with antigen alone. The mechanism of this enhanced antigen presentation was found to be due to a GM-CSF-dependent increase in the level of IL 1...
CD40 is strongly expressed by macrophages as well as other antigen-presenting cells (APCs), and functions as a receptor for the CD40 ligand (CD40L), which is abundant on activated CD4+ T cells. The CD40–CD40L interaction triggers several molecular events, including the activation of nuclear fa...
Presentation of MHC class I antigens by professional antigen-presenting cells (APC) is an important pathway in priming cytotoxic T lymphocyte responses in vivo. This study sought to identify the nature of the professional APC responsible for indirect class I presentation by examining a special featur...
et al. Stellate cells, hepatocytes, and endothelial cells imprint the Kupffer cell identity on monocytes colonizing the liver macrophage niche. Immunity 51, 638–654.e9 (2019). Article CAS PubMed PubMed Central Google Scholar Crispe, I. N. Liver antigen-presenting cells. J. Hepatol. 54, ...
Dendritic cells (DC) are antigen presenting cells (APC) with the unique ability to initiate an immune response. Immature DC are localized in peripheral tissues where they exert a sentinel function for incoming antigens (Ag). After Ag capture and exposure to inflammatory stimuli DC undergo maturati...