In assays of concanavalin A-induced blastogenesis of thymocytes, alveolar macrophages functioned as accessory cells. The anti-Ia antibody 7.2 interfered with this function, indicating that Ia antigens on canine alveolar macrophages are involved in interaction with T cells resulting in T cell ...
Aortic resident macrophages expand in situ via direct cell renewal. Induced depletion of intimal macrophages leads to thrombin-mediated endothelial cell contraction, progressive fibrin accumulation and formation of microthrombi that, once dislodged, cause blockade of vessels in several organs. Together the...
As phagocytosis by macrophages plays a critical role in the control of bacteria, we investigated the phagocytic activity of macrophages after resolution of inflammation. After resolution of primary pneumonia, murine alveolar macrophages (AMs) exhibited poor phagocytic capacity for several weeks. These ...
Importantly, antigen-mediated T-cell activation in TAC-induced HF implicates a central role for antigen presenting cells such as macrophages and DCs. Consistent with this notion, antibody-mediated depletion of CCR2+ monocytes and elimination of the early surge of macrophages into the heart during ...
orally, antigens or antigen-containing particles are phagocytosed by M cells in Peyer’s patches in the small intestine (aggregations of lymphoid tissue in the lowest portion of the small intestine) [168]. These cells deliver antigens to lymphoid tissues and resident macrophages and serve as ...
tuberculosis-infected macrophages release apoptotic vesicles with antigen-stimulating activity (19, 20). To evaluate whether apoptotic vesicle were involved in the observe response, we first tested whether apoptosis is occurring in the infected macrophage population by staining cells with annexin V, which...
How does the structure of a lymph node allow lymphocytes and macrophages to perform their protective function? Describe the function, characteristics, and location of epithelial cells. What is the function of cutaneous membrane? What attacks an antigen?
Killer T-cells are not macrophages. Macrophages are phagocytic cells of the innate immune system. They are professional antigen-presenting cells that...Become a member and unlock all Study Answers Start today. Try it now Create an account Ask a question Our experts can answer your tough ...
Subsets of myeloid antigen-presenting cells were characterized as follows: CD11bϩ F4/80ϩ macrophages, F4/80ϪCD11bϩCD11cϩ myeloid dendritic cells, and F4/80ϪCD11bϪ CD11cϩ lymphoid/plasmacytoid DC (all antibodies for this characterization were either FI...
(including PD-1), B cells and CD38+lymphocytes. Myeloid cells included macrophages, granulocytes and other CD11c+antigen-presenting cells (APCs) such as dendritic cells. Consistent with past work26, there was notable stromal cell heterogeneity based on the expression of SMA (distinguishing ...