Macroautophagy in quiescent and senescent cells: a pathway to longevity?Cellular quiescence – reversible exit from the cell cycle – is an important feature of many cell types important for organismal health. Aging and cellular dysfunction compromise the survival and reactivation of quiescent cells ...
(such as osteocalcin) help to counteract age-related cognitive decline, we identified a primary cilium–autophagy axis that regulates neuronal homeostasis and cognitive resilience. Osteocalcin promotes neuronal autophagy through its receptor GPR158 at the primary cilium; restoring this pathway in aged ...
Macroautophagy is a catabolic recycling pathway, which can be induced by various stress stimuli. Viruses are able to manipulate autophagy in the cells that they infect. The impact of autophagy on the innate immune response to viruses and its stimulatory role in antigen presentation to CD4+ T ...
Macroautophagy, which is a lysosomal pathway for the turnover of organelles and long-lived proteins, is a key determinant of cell survival and longevity. In this study, we show that neuronal macroautophagy is induced early in Alzheimer's disease (AD) and before β-amyloid (Aβ) deposits ext...
The autophagy pathway starts with the formation of a double-membrane cisternae, called a phagophore, which originates from the endoplasmic reticulum. The growth and expansion of the phagophore requires membranes from other compartments such as the Golgi complex, recycling endosomes, and the plasma me...
macroautophagy pathway that uses the specificity of heat shock protein 70 (HSP70) to misfolded proteins and also involves other protein partners, such as ... C Behl - 《Autophagy》 被引量: 116发表: 2011年 The stress-inducible HspB8-Bag3 complex induces the eIF2α kinase pathway: Implication...
Cell lines carrying a deletion of the ATG5 gene (encoding a protein in the Atg12–Atg5-Atg16 complex, which acts in part as an E3 ligase in the macroautophagy pathway [5]) show a loss of multiple macroautophagy-related ...
Macroautophagy is an evolutionarily conserved process that delivers diverse cellular contents to lysosomes for degradation. As our understanding of this pathway grows, so does our appreciation for its importance in disorders of the CNS. Once implicated p
Targeting the autophagy pathway may therefore represent an attractive treatment modality in AD‐induced lung fibrosis.doi:10.1002/cjp2.20Poornima MahavadiLars KnudsenShalini VenkatesanIngrid HennekeAndreas GuentherJohn Wiley & Sons, LtdThe Journal of Pathology: Clinical Research...
Mechanism of cargo selection in the cytoplasm to vacuole targeting pathway. Dev. Cell 3, 825–837 (2002). Article CAS PubMed PubMed Central Google Scholar Hanada, T. et al. The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy. J Biol. Chem. 282, ...