Studies suggest that autophagic processes and lysosomal function are critical to maintaining the function of quiescent cells, especially adult stem cells , throughout life. Findings also point to both pro-senescence and anti-senescence functions for macroautophagy depending on context. In this review, ...
Lysosomes are damaged in quiescent cells, and UPR regulators, IRE-1/XBP-1, promote lysosome repair for cell-cycle re-entry. Lysosome damage in quiescent cells is caused in part by macroautophagy and is suppressed in a synergistic way by inhibiting macroautophagy and boosting lysosome activity....
Furthermore, it should be considered whether ongoing macroautophagy in quiescent cells could be detrimental to their long-term function. Firstly, autophagic cell death has been reported to kill NSCs in response to certain stressors: could the autophagy-deficient NSCs in aged brains be the result ...