Macroautophagy is an evolutionarily conserved process that delivers diverse cellular contents to lysosomes for degradation. As our understanding of this pathway grows, so does our appreciation for its importance
In addition to Nrf2 signaling, it has been suggested that p53, the sequence-specific DNA-binding transcription factor, might play a critical role in mediating CMA-MA crosstalk in CNS diseases. A study by Tasdemir et al. described that p53 directly regulates autophagy genes which activate the MA...
The failure to clear misfolded or aggregated proteins from the cytoplasm of nerve cells and glia is a common pathogenic event in a variety of neurodegenerative disorders. This might be causally related to defects in the major proteolytic systems, i.e., the ubiquitin-proteasomal system and the aut...
In neurons of the CNS and also of the peripheral nervous system (PNS), autophagosome biogenesis starts in neurites and synaptic terminal regions in the distal axon, being then transported back to the cell soma by retrograde movement to fuse with active lysosomes [62]. Autophagosomes undergo ...
In neurons of the CNS and also of the peripheral nervous system (PNS), autophagosome biogenesis starts in neurites and synaptic terminal regions in the distal axon, being then transported back to the cell soma by retrograde movement to fuse with active lysosomes [62]. Autophagosomes undergo ...
Macroautophagy is a “cell cleansing” process that rids cells of protein aggregates and damaged organelles that may contribute to disease pathogenesis and the dysfunctions associated with aging. Measures which boost longevity and health span in rodents typically up-regulate macroautophagy, and it has...