Zhou et al. N6 -Methyladenosine Reader Protein YT521-B Homology Domain-Containing 2 Suppresses Liver Steatosis by Regulation of mRNA Stability of Lipogenic Genes.Hepatology, 2021 Zhu et al. Crosstalk between m6A modification and alternative splicing during cancer progression.Clin TranslMed, 2023 爱基百...
5. Mendel M, Delaney K, Pandey RR, Chen KM, Wenda JM, Vågbø CB, Steiner FA, Homolka D, Pillai RS. Splice site m6A methylation prevents binding of U2AF35 to inhibit RNA splicing. Cell. 2021 Jun 10;184(12):3125-3142.e25. doi: 10.1016/j.cell.2021.03.062. 6. Chen L, Fu Y...
[1] Li, Z., et al. (2015) "Exon-intron circular RNAs regulate transcription in the nucleus" Nat Struct Mol Biol 22(3):256-64 [PMID: 25664725] [2] Conn, V. M., et al. (2017) "A circRNA from SEPALLATA3 regulates splicing of its cognate mRNA through R-loop formation" Nat Plant...
28. Zhao, X. et al. FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis. Cell Res. 24, 1403–1419 (2014). 29. Liu, N. et al. N(6)-methyladenosine-dependent ...
10. Zhong, S., et al.,MTA is an Arabidopsis messenger RNA adenosine methylase and interacts with a homolog of a sex-specific splicing factor.Plant Cell, 2008.20(5): p. 1278-88. 11. Yoon, K.J., et al.,Temporal Control...
m6A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination. Nature. 2016;540:301-4.Haussmann IU, Bodi Z, Sanchez-Moran E, Mongan NP, Archer N, Fray RG and Soller M (2016) m6A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination. ...
mRNA regions are devoid of such modification despite the relatively equal frequency of the DRACH motifs for METT3/14 to act on. The current study from He lab revealed that the internal exons are largely suppressed by the exon junction complex (EJC), which is deposited during pre-mRNA splicing...
剪接(Splicing) 在METTL3敲除细胞中,m6A丰度与差异剪接外显子相关,表明其在可变剪接中的作用。对MeRIP数据中的外显子m6A motifs分析结果显示m6A发生在5'和3'剪接位点附近。由差异剪接位点选择引起的可变剪接主要受丝氨酸/精氨酸富集的剪接因子(SRSF)与剪接位点附近顺式调控序列结合的调控,从而导致外显子被内含或排除...
14 Xiao, W. et al. Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing.Mol Cell61, 507-519, doi:10.1016/j.molcel.2016.01.012 (2016). 15 Zhang, C. et al. METTL3 and N6-Methyladenosine Promote Homologous Recombination-Mediated Repair of DSBs by Modulating DNA-RNA Hybrid Accumulation.Mo...
剪接(Splicing) 在METTL3敲除细胞中,m6A丰度与差异剪接外显子相关,表明其在可变剪接中的作用。对MeRIP数据中的外显子m6A motifs分析结果显示m6A发生在5'和3'剪接位点附近。由差异剪接位点选择引起的可变剪接主要受丝氨酸/精氨酸富集的剪接因子(SRSF)与剪接位点附近顺式调控序列结合的调控,从而导致外显子被内含或排除...