Macrophages are innateimmunecellsthatadopt diverse activation states in response to their microenvironment. Editingmacrophage activationto dampeninflammatory diseasesby promoting therepolarizationof inflammatory (M1) macrophages toanti-inflammatory(M2) macrophages is of high interest. Here, we find that mouse ...
Compared to HC, significantly increased M1-polarization was observed for MDD patients in the presence of FCS, however, polarization in AS enriched media determined an increased M2-polarization in patients. Moreover, female MDD patients exhibited increased M1- and decreased M2-polarization in both ...
protects cells from M1-inducing stimuli LPS and IFN-γ. In addition shape- but not cytokine-induced polarization is abrogated when actin and actin/myosin contractility are inhibited by pharmacological agents, suggesting a role for the cytoskeleton in the control of macrophage polarization by cell geom...
Macrophage M1/M2 Polarization Dynamically Adapts to Changes in Cytokine Microenvironments in Cryptococcus neoformans Infection The outcome of cryptococcal pneumonia correlates with local macrophage polarization status, as M1 and M2 polarization marks protective and nonprotective re... M.,J.,Davis,... -...
小鼠巨噬,也可以参考此方法,也可以加上F4/80、CD11b作为上级门,也可以加上巨噬细胞功能标记,可参考mTORC1-mediated polarization of M1 macrophages and their accumulation in the liver correlate with immunopathology in fatal ehrlichiosis [4]。 但是,有不少FLOWER仍然反映,CD206实在染不好啊,分不开,那怎么办...
近日,来自中国科技大学第一附属医院的研究者们在Int J Biol Sci杂志上发表了题为“TREM2 promotes macrophage polarization from M1 to M2 and suppresses osteoarthritis through the NF-κB/CXCL3 axis”的文章,该研究表明TREM2通过NF-κB/CXCL3轴调控,促进OA期间巨噬细胞从M1向M2极化,从而改善OA的病理状态。。
参考文献 Li Y-F, Ren X, Zhang L, Wang Y-H and Chen T (2022) Microglial polarization in TBI: Signaling pathways and influencing pharmaceuticals. Front. Aging Neurosci. 14:901117. doi: 10.3389/fnagi.2022.901117 编译作者: 原代美少女 (Brainnews创作团队) 校审: Simon (Brainnews编辑部)
Microglia in spinal cord injury: M1/M2 phenotypic polarization and neurotoxic/neuroprotective effects Li Chuanhong, Yu Xing, Yang Yongdong, Zhao He PDF 147 摘要/Abstract 摘要: 文题释义: 小胶质细胞:中枢神经系统内常驻的单核-吞噬细胞群体,它起源于卵黄囊胚外中胚层,在胚胎发育过程中定植到神经外胚层,随...
Raggi F, Pelassa S, Pierobon D et al. Regulation of Human Macrophage M1–M2 Polarization Balance by Hypoxia and the Triggering Receptor Expressed on Myeloid Cells-1. Front Immunol. 2017; 8: 1097.小鼠的巨噬细胞检测，也可以参考此方法，加上F4/80和CD11b作为上级门，圈出总的巨噬细胞。
近日,来自中国科技大学第一附属医院的研究者们在Int J Biol Sci杂志上发表了题为“TREM2 promotes macrophage polarization from M1 to M2 and suppresses osteoarthritis through the NF-κB/CXCL3 axis”的文章,该研究表明TREM2通过NF-κB/CXCL3轴调控,促进OA期间巨噬细胞从M1向M2极化,从而改善OA的病理状态。。