Paulk, J. Lysosome-targeting chimeras evolve. Nat Chem Biol 17, 931–933 (2021). https://doi.org/10.1038/s41589-021-00835-1 Download citation Published19 August 2021 Issue DateSeptember 2021 DOIhttps://doi.org/10.1038/s41589-021-00835-1 Subjects Chemical tools Post-translational modifications...
R. Chemically tunable mucin chimeras assembled on living cells. Proc. Natl Acad. Sci. USA 112, 12574–12579 (2015). ADS CAS PubMed PubMed Central Google Scholar Vidal, S., Montero, J.-L., Leydet, A. & Morère, A. A flexible route to mannose 6-phosphonate functionalized derivatives....
The first lysosome targeting chimeras (LYTACs) targeted extracellular and membrane proteins for degradation by bridging a target protein to an endogenous lysosome targeting receptor, the cation-independent mannose-6-phosphate receptor (CI-M6PR). Here we developed LYTACs that engage the asialo...
Anti-tumor immunotherapy using engineered bacterial outer membrane vesicles fused to lysosome-targeting chimeras mediated by transferrin receptor 内吞作用 转铁蛋白受体 溶酶体 体内 转铁蛋白 嵌合体(遗传学) 小泡 细胞生物学 化学 生物 受体 膜 生物化学 酶 生物技术 基因 作者 Ling-Yan Su,Yang Tian,Qiang...
ArticleAnti-tumor immunotherapy using engineeredbacterial outer membrane vesicles fused tolysosome-targeting chimeras mediated bytransferrin receptorGraphical abstractHighlightsd A gene-encoded TfR-LYTAC is developed for lysosomaldegradation of extracellular proteinsd TfR-LYTAC is eff i ciently targetedto thetum...
Several previous studies have also demonstrated the enhanced antigen-specific immune responses of such antigen/LAMP chimeras of vaccinia virus vector and DNA plasmid vaccine preparations (Marques et al., 2003, Ruff et al., 1997, Wu et al., 1995), including studies of a dengue virus vaccine (...
Paulk, J. Lysosome-targeting chimeras evolve. Nat Chem Biol 17, 931–933 (2021). https://doi.org/10.1038/s41589-021-00835-1 Download citation Published19 August 2021 Issue DateSeptember 2021 DOIhttps://doi.org/10.1038/s41589-021-00835-1 Springer Nature America, Inc. This article is cited...