Protein-degradation platforms such as proteolysis-targeting chimaeras (PROTACs)1,2 and others (for example, dTAGs3, Trim-Away4, chaperone-mediated autophagy targeting5 and SNIPERs6) have been developed for proteins that are typically difficult to target; however, these methods involve the ...
Lysosome Targeting Chimaeras for Glut1-Facilitated TargetedProtein DegradationJinyan Luo, § Quan Gao, § Kui Tan, Shiling Zhang, Weiwei Shi, Lei Luo, Zhiying Li, Ghada E. Khedr,Jie Chen, Youwei Xu, Ming Luo, Qi Xing, and Jin Geng*Cite This: https://doi.org/10.1021/jacs.4c02463 Rea...