Lysosome Targeting Chimaeras for Glut1-Facilitated TargetedProtein DegradationJinyan Luo, § Quan Gao, § Kui Tan, Shiling Zhang, Weiwei Shi, Lei Luo, Zhiying Li, Ghada E. Khedr,Jie Chen, Youwei Xu, Ming Luo, Qi Xing, and Jin Geng*Cite This: https://doi.org/10.1021/jacs.4c02463 Rea...
These initial lysosome-targeting chimaeras, which we term LYTACs, consist of a small molecule or antibody fused to chemically synthesized glycopeptide ligands that are agonists of the cation-independent mannose-6-phosphate receptor (CI-M6PR). We use LYTACs to develop a CRISPR interference screen ...