Ubiquitin recruiting chimera: more than just a PROTAC Tatyana A. Grigoreva Daria S. Novikova Vyacheslav G. Tribulovich Biology Direct (2024) Targeted protein degradation in hematologic malignancies: clinical progression towards novel therapeutics Yupiao Feng Xinting Hu Xin Wang Biomarker Research...
Lysosome‐targeting chimera (LYTAC): A silver bullet for targeted degradation of oncogenic membrane proteinsdoi:10.1002/mog2.64Zheng, QingquanGuo, JiaweiMa, RuiPu, WenchenMedcomm: Oncology
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The lysosome-targeting chimera (LYTAC) approach has shown promise for the targeted degradation of secreted and membrane proteins via lysosomes. However, there have been challenges in design, development, and targeting. Here, we have designed a genetically engineered transferrin receptor (TfR)-mediated ...
West Nile premembrane-envelope genetic vaccine encoded as a chimera containing the transmembrane and cytoplasmic domains of a lysosome-associated membrane protein: increased cellular concentration of the transgene product, targeting to the MHC II compartment, and enhanced neutralizing antibody response...
Provided is preparation for a lysosome-targeting nucleic acid chimera, and an application of constructing a lysosome-targeting chimera on the basis of the nucleic acid in specific degradation of intracellular and extracellular biological macromolecules and preparation of related drugs.HAN, DA...